Detalhe da pesquisa
1.
Improved yield of recombinant human IFN-α2b from mammalian cells using heterologous signal peptide approach.
Protein Expr Purif
; 198: 106125, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35659600
2.
TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex.
J Immunol
; 204(7): 1943-1953, 2020 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32102902
3.
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.
Bioorg Med Chem Lett
; 41: 127973, 2021 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33753261
4.
Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1.
Biotechnol Lett
; 43(4): 757-765, 2021 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-33415569
5.
Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Bioorg Med Chem Lett
; 29(12): 1454-1458, 2019 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31005442
6.
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Bioorg Med Chem Lett
; 29(6): 821-825, 2019 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30691925
7.
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Bioorg Med Chem Lett
; 29(20): 126675, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31521475
8.
Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Bioorg Med Chem Lett
; 30(2): 126771, 2020 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31859161
9.
Unlocking the secrets of the gatekeeper: methods for stabilizing and crystallizing GPCRs.
Biochim Biophys Acta
; 1828(11): 2583-91, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23871992
10.
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
J Invest Dermatol
; 141(9): 2272-2279, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33744298
11.
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
EMBO Mol Med
; 13(3): e13167, 2021 03 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33512066
12.
Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.
J Exp Med
; 198(1): 99-109, 2003 Jul 07.
Artigo
Inglês
| MEDLINE | ID: mdl-12847139
13.
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Bioorg Med Chem Lett
; 20(15): 4639-44, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20579874
14.
Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies.
MAbs
; 12(1): 1755069, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32343620
15.
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Bioorg Med Chem Lett
; 19(13): 3669-73, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19477642
16.
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Bioorg Med Chem Lett
; 19(13): 3664-8, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19428244
17.
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Bioorg Med Chem Lett
; 19(13): 3674-8, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19406640
18.
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Acta Crystallogr F Struct Biol Commun
; 75(Pt 5): 385-391, 2019 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31045568
19.
Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
J Med Chem
; 51(11): 3313-7, 2008 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-18457381
20.
BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Bioorg Med Chem Lett
; 18(3): 1017-21, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18166458