Pesquisa | Secretaria de Estado da Saúde

1.

PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program.

Hashimoto, Masao; Araki, Koichi; Cardenas, Maria A; Li, Peng; Jadhav, Rohit R; Kissick, Haydn T; Hudson, William H; McGuire, Donald J; Obeng, Rebecca C; Wieland, Andreas; Lee, Judong; McManus, Daniel T; Ross, James L; Im, Se Jin; Lee, Junghwa; Lin, Jian-Xin; Hu, Bin; West, Erin E; Scharer, Christopher D; Freeman, Gordon J; Sharpe, Arlene H; Ramalingam, Suresh S; Pellerin, Alex; Teichgräber, Volker; Greenleaf, William J; Klein, Christian; Goronzy, Jorg J; Umaña, Pablo; Leonard, Warren J; Smith, Kendall A; Ahmed, Rafi.

Nature ; 610(7930): 173-181, 2022 10.

Artigo Inglês | MEDLINE | ID: mdl-36171288

2.

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.

Zhou, Lei; Chu, Coco; Teng, Fei; Bessman, Nicholas J; Goc, Jeremy; Santosa, Endi K; Putzel, Gregory G; Kabata, Hiroki; Kelsen, Judith R; Baldassano, Robert N; Shah, Manish A; Sockolow, Robbyn E; Vivier, Eric; Eberl, Gérard; Smith, Kendall A; Sonnenberg, Gregory F.

Nature ; 568(7752): 405-409, 2019 04.

Artigo Inglês | MEDLINE | ID: mdl-30944470

3.

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.

Owen, David L; Mahmud, Shawn A; Vang, Kieng B; Kelly, Ryan M; Blazar, Bruce R; Smith, Kendall A; Farrar, Michael A.

J Immunol ; 200(12): 3926-3933, 2018 06 15.

Artigo Inglês | MEDLINE | ID: mdl-29728511

4.

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

Kalia, Vandana; Sarkar, Surojit; Subramaniam, Shruti; Haining, W Nicholas; Smith, Kendall A; Ahmed, Rafi.

Immunity ; 32(1): 91-103, 2010 Jan 29.

Artigo Inglês | MEDLINE | ID: mdl-20096608

5.

Conjugated block copolymer photovoltaics with near 3% efficiency through microphase separation.

Guo, Changhe; Lin, Yen-Hao; Witman, Matthew D; Smith, Kendall A; Wang, Cheng; Hexemer, Alexander; Strzalka, Joseph; Gomez, Enrique D; Verduzco, Rafael.

Nano Lett ; 13(6): 2957-63, 2013 Jun 12.

Artigo Inglês | MEDLINE | ID: mdl-23687903

6.

Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands.

Wang, Lei; Maharjan, Chandra K; Borcherding, Nicholas; Master, Rohan P; Mo, Jiao; Tithi, Tanzia Islam; Kim, Myung-Chul; Carelock, Madison E; Master, Anuj P; Gibson-Corley, Katherine N; Kolb, Ryan H; Smith, Kendall A; Zhang, Weizhou.

bioRxiv ; 2024 Apr 30.

Artigo Inglês | MEDLINE | ID: mdl-38712046

7.

Pillars Article: T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity. J. Immunol. 1978. 120: 2027-2032.

Gillis, Steven; Ferm, Mary M; Ou, Winny; Smith, Kendall A.

J Immunol ; 197(1): 5-10, 2016 07 01.

Artigo Inglês | MEDLINE | ID: mdl-27317732

8.

Smallpox: can we still learn from the journey to eradication?

Smith, Kendall A.

Indian J Med Res ; 137(5): 895-9, 2013 May.

Artigo Inglês | MEDLINE | ID: mdl-23760373

9.

The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response.

Smith, Kendall A; Popmihajlov, Zoran.

Immunol Rev ; 224: 124-40, 2008 Aug.

Artigo Inglês | MEDLINE | ID: mdl-18759924

10.

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.

Ha, Sang-Jun; West, Erin E; Araki, Koichi; Smith, Kendall A; Ahmed, Rafi.

Immunol Rev ; 223: 317-33, 2008 Jun.

Artigo Inglês | MEDLINE | ID: mdl-18613845

11.

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory.

Toumi, Ryma; Yuzefpolskiy, Yevgeniy; Vegaraju, Adithya; Xiao, Hanxi; Smith, Kendall A; Sarkar, Surojit; Kalia, Vandana.

Cell Rep ; 39(2): 110632, 2022 04 12.

Artigo Inglês | MEDLINE | ID: mdl-35417685

12.

Following the cytokine signaling pathway to leukemogenesis: a chronology.

Smith, Kendall A; Griffin, James D.

J Clin Invest ; 118(11): 3564-73, 2008 Nov.

Artigo Inglês | MEDLINE | ID: mdl-18982163

13.

The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination.

Liou, Hsiou-Chi; Smith, Kendall A.

Immunol Cell Biol ; 89(1): 27-32, 2011 Jan.

Artigo Inglês | MEDLINE | ID: mdl-20975733

14.

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.

Feinerman, Ofer; Jentsch, Garrit; Tkach, Karen E; Coward, Jesse W; Hathorn, Matthew M; Sneddon, Michael W; Emonet, Thierry; Smith, Kendall A; Altan-Bonnet, Grégoire.

Mol Syst Biol ; 6: 437, 2010 Nov 30.

Artigo Inglês | MEDLINE | ID: mdl-21119631

15.

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo.

Blattman, Joseph N; Grayson, Jason M; Wherry, E John; Kaech, Susan M; Smith, Kendall A; Ahmed, Rafi.

Nat Med ; 9(5): 540-7, 2003 May.

Artigo Inglês | MEDLINE | ID: mdl-12692546

16.

The quantal theory of immunity.

Smith, Kendall A.

Cell Res ; 16(1): 11-9, 2006 Jan.

Artigo Inglês | MEDLINE | ID: mdl-16467871

17.

Highly Flexible Self-Assembled V2O5 Cathodes Enabled by Conducting Diblock Copolymers.

An, Hyosung; Mike, Jared; Smith, Kendall A; Swank, Lisa; Lin, Yen-Hao; L Pesek, Stacy; Verduzco, Rafael; Lutkenhaus, Jodie L.

Sci Rep ; 5: 14166, 2015 Sep 22.

Artigo Inglês | MEDLINE | ID: mdl-26391053

18.

[The HIV vaccine].

Smith, Kendall A.

Zhonghua Nan Ke Xue ; 10(10): 723-8, 2004 Oct.

Artigo Chinês | MEDLINE | ID: mdl-15562781

19.

Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.

Smith, Kendall A.

Front Immunol ; 5: 29, 2014.

Artigo Inglês | MEDLINE | ID: mdl-24550914

20.

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.

West, Erin E; Jin, Hyun-Tak; Rasheed, Ata-Ur; Penaloza-Macmaster, Pablo; Ha, Sang-Jun; Tan, Wendy G; Youngblood, Ben; Freeman, Gordon J; Smith, Kendall A; Ahmed, Rafi.

J Clin Invest ; 123(6): 2604-15, 2013 Jun.

Artigo Inglês | MEDLINE | ID: mdl-23676462

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PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program.

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

Conjugated block copolymer photovoltaics with near 3% efficiency through microphase separation.

Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands.

Pillars Article: T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity. J. Immunol. 1978. 120: 2027-2032.

Smallpox: can we still learn from the journey to eradication?

The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response.

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory.

Following the cytokine signaling pathway to leukemogenesis: a chronology.

The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination.

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo.

The quantal theory of immunity.

Highly Flexible Self-Assembled V2O5 Cathodes Enabled by Conducting Diblock Copolymers.

[The HIV vaccine].

Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.