[Changes in the ultrastructure of staphylococci in kidney tissue in experimental infection]. / Izmenenie ul'trastruktury stafilokokkov v pochechnoi tkani pri eksperimental'noi infektsii

A study of ultrathin sections fo the kidney tissue of mice infected with staphylococci showed intracellular localization of the bacteria. In vivo there occurred a morphological reconstruction of external layers of the cell wall of staphylococci, and lysis of individual staphylococci. The middle part of the cell wall and the cytoplasmic membrane proved to be the structures the most stable to lysis. Specific changes of bacteria similar to the changes noted with the action of penicillin on staphylococci in vitro followed effective penicillin therapy of mice infected with staphylococci.

[Use of prodigioza in the overall treatment of chronic osteomyelitis]. / Primenenie prodigiozana v kompleksnom lechenii khronicheskogo osteomielita

Treatment of 188 patients suffering from chronic osteomyelitis of various etiology and localization with prodigiosan, a bacterial lipopolysaccharide favoured an increase in the nonspecific immunobiological reactivity: the phagocytic activity and leucocytic intensity increased, the average titers of iso- and heteroagglutinins, as well as the complementary activity of the serum became higher. The results of the clinico-laboratory studies are indicative of advisable use of prodigiosan in complex therapy of cases with chronic osteomyelitis.