Detalhe da pesquisa
1.
Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43.
Bioorg Med Chem Lett
; 84: 129211, 2023 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36863494
2.
Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum.
Mol Cell Biochem
; 476(10): 3729-3744, 2021 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-34091807
3.
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Bioorg Chem
; 102: 104003, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32771768
4.
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells.
Bioorg Med Chem Lett
; 27(7): 1561-1565, 2017 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28256372
5.
Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation.
Bioorg Med Chem
; 24(18): 4241-4245, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27427397
6.
Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane.
Chembiochem
; 16(13): 1840-1853, 2015 Sep 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26097061
7.
Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications.
Org Biomol Chem
; 13(29): 8067-70, 2015 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26134592
8.
Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity.
Bioorg Med Chem Lett
; 24(15): 3430-3, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24951329
9.
Cn-AMP2 from green coconut water is an anionic anticancer peptide.
J Pept Sci
; 20(12): 909-15, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25234689
10.
Synthetic oligoureas of metaphenylenediamine mimic host defence peptides in their antimicrobial behaviour.
Bioorg Med Chem Lett
; 23(9): 2518-21, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23541668
11.
Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes.
Eur Biophys J
; 41(8): 687-93, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22782185
12.
A therapeutic update on PARP inhibitors: implications in the treatment of glioma.
Drug Discov Today
; 26(2): 532-541, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33157194
13.
Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma.
Eur J Med Chem
; 225: 113751, 2021 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34391032
14.
Biophysical studies on the antimicrobial activity of linearized esculentin 2EM.
Biochim Biophys Acta Biomembr
; 1862(2): 183141, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31790693
15.
Towards a chemo-enzymatic method for the asymmetric synthesis of beta-amino tertiary alcohols.
Org Biomol Chem
; 7(24): 5163-5, 2009 Dec 21.
Artigo
Inglês
| MEDLINE | ID: mdl-20024112
16.
Identification of C-ß-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem Biol
; 14(7): 1460-1470, 2019 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31243960
17.
Helix persistence and breakdown in oligoureas of metaphenylenediamine: apparent diastereotopicity as a spectroscopic marker of helix length in solution.
J Am Chem Soc
; 130(45): 15193-202, 2008 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-18844355
18.
Towards identifying potent new hits for glioblastoma.
Medchemcomm
; 9(11): 1850-1861, 2018 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30568753
19.
A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (+/-)-crispine A.
Chem Commun (Camb)
; (35): 3640-2, 2007 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-17728879
20.
Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N'-diarylureas and diaryl ethers: advantages of a relay axis.
Chem Commun (Camb)
; (7): 754-6, 2007 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-17392973