Detalhe da pesquisa
1.
Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods.
Bioorg Med Chem Lett
; 84: 129193, 2023 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36822300
2.
Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.
Protein Expr Purif
; 179: 105796, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33221505
3.
A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation.
Bioorg Med Chem Lett
; 29(9): 1074-1078, 2019 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30857747
4.
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Bioorg Med Chem Lett
; 26(20): 5092-5097, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27658368
5.
In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir.
J Infect Dis
; 209(5): 668-75, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24154738
6.
Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 24(3): 949-53, 2014 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24412066
7.
Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.
Bioorg Med Chem Lett
; 24(12): 2707-11, 2014 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24815509
8.
A simple statistical test to infer the causality of target/phenotype correlation from small molecule phenotypic screens.
Bioinformatics
; 28(3): 301-5, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22155864
9.
Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs.
Bioorg Med Chem Lett
; 23(14): 4216-20, 2013 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23743277
10.
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors.
Bioorg Med Chem Lett
; 21(21): 6264-9, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21958546
11.
Overview of artificial neural networks.
Methods Mol Biol
; 458: 15-23, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-19065803
12.
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
J Med Chem
; 49(22): 6549-60, 2006 Nov 02.
Artigo
Inglês
| MEDLINE | ID: mdl-17064073
13.
Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries.
Methods Mol Biol
; 1289: 43-53, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25709032
14.
Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.
ACS Med Chem Lett
; 5(2): 124-7, 2014 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24900784
15.
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor ß agonist in clinical trials for the treatment of dyslipidemia.
J Med Chem
; 57(10): 3912-23, 2014 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-24712661
16.
Design of libraries targeting protein-protein interfaces.
ChemMedChem
; 8(5): 726-32, 2013 May.
Artigo
Inglês
| MEDLINE | ID: mdl-23436619
17.
A Crowd-Based Process and Tool for HTS Hit Triage.
Mol Inform
; 32(4): 337-45, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-27481590
18.
Automated pharmacophore query optimization with genetic algorithms - a case study using the MC4R system.
J Chem Inf Model
; 47(4): 1545-52, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17555310
19.
Enhancing specificity and sensitivity of pharmacophore-based virtual screening by incorporating chemical and shape features--a case study of HIV protease inhibitors.
J Chem Inf Model
; 46(3): 1236-44, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16711743
20.
Development of neural network QSPR models for Hansch substituent constants. 1. Method and validations.
J Chem Inf Comput Sci
; 44(1): 147-53, 2004.
Artigo
Inglês
| MEDLINE | ID: mdl-14741021