RESUMO
BACKGROUND: Obesity causes secondary hypogonadism (HG) in men. Standard testosterone (T) replacement therapy improves metabolic parameters but leads to infertility. OBJECTIVE: To evaluate clomiphene citrate (CC) treatment of adult men with male obesity-associated secondary hypogonadism (MOSH). DESIGN: Single-center, randomized, double-blind, placebo-controlled trial. PARTICIPANTS: Seventy-eight men aged 36.5 ± 7.8 years with a body mass index (BMI) > 30 kg/m2, total testosterone (TT) ≤ 300 ng/dL, and symptoms in the ADAM questionnaire. INTERVENTION: Random allocation to receive 50 mg CC or placebo (PLB) for 12 weeks. OUTCOMES: (1) Clinical features: ADAM and sexual behavior questionnaires; (2) hormonal profile: serum TT, free T, estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG); (3) body composition: BMI, waist circumference, and bioelectric impedance analysis; (4) metabolic profile: blood pressure, fasting blood glucose, HbA1c, insulin, HOMA-IR, and lipid profile; (5) endothelial function: flow-mediated dilation of the brachial artery, quantitative assessment of endothelial progenitor cells and serum sICAM-1, sVCAM-1, and selectin-sE levels; (6) safety aspects: hematocrit, serum prostate-specific antigen, International Prostate Symptom Score, and self-reported adverse effects. RESULTS: There was an improvement in one sexual complaint (weaker erections; P < 0.001); increases (P < 0.001) in TT, free T, E2, LH, FSH, and SHBG; and improvements in lean mass (P < 0.001), fat-free mass (P = 0.004), and muscle mass (P < 0.001) in the CC group. CC reduced HDL (P < 0.001). No statistically significant differences were seen in endothelial function. CONCLUSIONS: CC appeared to effectively improve the hormonal profile and body composition. CC may be an alternative treatment for MOSH in adult men.
Assuntos
Clomifeno/uso terapêutico , Antagonistas de Estrogênios/uso terapêutico , Hipogonadismo/tratamento farmacológico , Hipogonadismo/etiologia , Obesidade/complicações , Adulto , Método Duplo-Cego , Humanos , MasculinoRESUMO
A síndrome do túner do carpo (STC) é uma neuropatia periférica cinco vezes mais freqüente no sexo feminino, causada pela compressão do nervo mediano na altura do punho. O sintoma marcante dessa síndrome é a parestesia matinal no território sensitivo deste nervo. O diagnóstico é basicamente clínico. Exames úteis para diagnóstico diferencial são a eletroneuromiografia e a RNM. O tratamento de escolha inicial deve ser conservador. Para os casos refratários está indicada a liberação cirúrgica do nervo mediano através da incisão do ligamento transverso do carpo, seja por via aberta ou endoscópica. É importante que o médico explique ao paciente as possíveis causas de tal patologia, pois a abstinência de atividades agravantes é fundamental para a cura definitiva