RESUMO
OBJECTIVE: Studies suggest that prenatal exposure to traffic-related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early-life weight gain. METHODS: The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months). RESULTS: A one standard deviation (1-SD: 2 ppb) increase in prenatal non-freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways (P = 0.03). A 1-SD (10 ng mL-1 ) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48). CONCLUSIONS: Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.
Assuntos
Adipocinas/sangue , Peso Corporal/fisiologia , Sangue Fetal/metabolismo , Obesidade Infantil/etiologia , Efeitos Tardios da Exposição Pré-Natal/sangue , Poluição Relacionada com o Tráfego/efeitos adversos , Adulto , Poluentes Atmosféricos/efeitos adversos , Poluentes Atmosféricos/análise , Poluição do Ar/efeitos adversos , Poluição do Ar/análise , California , Criança , Feminino , Humanos , Lactente , Recém-Nascido , Modelos Lineares , Masculino , Mães , Gravidez , Poluição Relacionada com o Tráfego/análise , Aumento de Peso/fisiologiaRESUMO
Inspection of the Vineland social Maturity Scale scores of a representative sample of 150 nonretarded children between the ages of 2 weeks and 36 months revealed that the social ages of most of these children using the original norm table were consistently higher than their chronological ages. A table of adjusted Vineland ages based on the performance of these children was provided, along with the original Vineland norms. Comparison of the original and adjusted scores suggests that the social ages on the Vineland may be overestimated in the 1- to 2-year range.