Detalhe da pesquisa
1.
Synthesis and biological evaluation of atropisomeric tetrahydroisoquinolines overcoming docetaxel resistance in triple-negative human breast cancer cells.
Bioorg Chem
; 137: 106573, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37229969
2.
Anti-Inflammatory Activity of Glabralactone, a Coumarin Compound from Angelica sinensis, via Suppression of TRIF-Dependent IRF-3 Signaling and NF-κB Pathways.
Mediators Inflamm
; 2022: 5985255, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35586367
3.
Catalytic and Enantioselective Control of the C-N Stereogenic Axis via the Pictet-Spengler Reaction.
Angew Chem Int Ed Engl
; 60(22): 12279-12283, 2021 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33651459
4.
Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion.
J Am Chem Soc
; 140(48): 16428-16432, 2018 12 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30427680
5.
The roles of IP3 receptor in energy metabolic pathways and reactive oxygen species homeostasis revealed by metabolomic and biochemical studies.
Biochim Biophys Acta
; 1853(11 Pt A): 2937-44, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26235438
6.
Design, synthesis, and anticancer activity of C8-substituted-4'-thionucleosides as potential HSP90 inhibitors.
Bioorg Med Chem
; 24(16): 3418-28, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27283788
7.
Regio- and stereoselective synthesis of 2'-ß-substituted-fluoroneplanocin A analogues as potential anticancer agents.
Org Biomol Chem
; 13(35): 9236-48, 2015 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-26224319
8.
Synthesis and biological evaluation of carbocyclic analogues of pachastrissamine.
Mar Drugs
; 13(2): 824-37, 2015 Feb 03.
Artigo
Inglês
| MEDLINE | ID: mdl-25654428
9.
Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity.
Bioorg Med Chem
; 21(4): 1006-17, 2013 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23294831
10.
All-round catalytic and atroposelective strategy via dynamic kinetic resolution for N-/2-/3-arylindoles.
Nat Commun
; 14(1): 5502, 2023 Sep 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37679348
11.
Organocatalytic Atroposelective Synthesis of Isoquinolines via Dynamic Kinetic Resolution.
Org Lett
; 24(4): 1077-1082, 2022 Feb 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35076251
12.
A Novel cytarabine analog evokes synthetic lethality by targeting MK2 in p53-deficient cancer cells.
Cancer Lett
; 497: 54-65, 2021 01 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33075425
13.
Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer.
J Cancer Prev
; 24(4): 217-223, 2019 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31950021
14.
A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer.
Biochem Pharmacol
; 158: 84-94, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30292755
15.
Synthesis, structural characterization and biological evaluation of 4'-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides.
Arch Pharm Res
; 40(5): 537-549, 2017 May.
Artigo
Inglês
| MEDLINE | ID: mdl-27615010
16.
Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation.
Oncotarget
; 7(23): 34395-419, 2016 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27284014
17.
Antitumor activity of phenanthroindolizidine alkaloids is associated with negative regulation of Met endosomal signaling in renal cancer cells.
Chem Biol
; 22(4): 504-515, 2015 Apr 23.
Artigo
Inglês
| MEDLINE | ID: mdl-25865310
18.
Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents.
J Med Chem
; 58(19): 7749-62, 2015 Oct 08.
Artigo
Inglês
| MEDLINE | ID: mdl-26393416
19.
Design, synthesis and cellular metabolism study of 4'-selenonucleosides.
Future Med Chem
; 7(13): 1643-55, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26399780
20.
Synthesis and biological evaluation of 2'-substituted-4'-selenoribofuranosyl pyrimidines as antitumor agents.
Arch Pharm Res
; 38(6): 966-72, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25239109