Detalhe da pesquisa
1.
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Mol Cell
; 37(1): 102-11, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20129059
2.
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Nature
; 458(7239): 732-6, 2009 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-19360080
3.
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.
Blood
; 116(9): 1515-23, 2010 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-20525923
4.
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Biochem J
; 430(3): 461-76, 2010 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20632995
5.
Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry.
Cell Biochem Biophys
; 67(1): 139-47, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23754621
6.
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover.
Cancer Res
; 71(8): 3042-51, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21487042
7.
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.
Genes Cancer
; 1(7): 708-16, 2010 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21779466
8.
Assays for proteasome inhibition.
Methods Mol Med
; 85: 163-72, 2003.
Artigo
Inglês
| MEDLINE | ID: mdl-12710207
9.
Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.
Clin Cancer Res
; 15(12): 3912-6, 2009 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19509147