Natural IgG protects against early dissemination of vesicular stomatitis virus.

Neonatal Fc receptor (FcRn) recycles immunoglobulin G, and inhibition of FcRn is used clinically for treatment of autoimmune diseases. In this work, using the vesicular stomatitis virus (VSV) mouse infection model system, we determined the role of FcRn during virus infection. While induction of neutralizing antibodies and long-term protection of these antibodies was hardly affected in FcRn deficient mice, FcRn deficiency limited the amount of natural IgG (VSV-specific) antibodies. Lack of natural antibodies (nAbs) limited early control of VSV in macrophages, accelerated propagation of virus in several organs, led to the spread of VSV to the neural tissue resulting in fatal outcomes. Adoptive transfer of natural IgG into FcRn deficient mice limited early propagation of VSV in FcRn deficient mice and enhanced survival of FcRn knockout mice. In line with this, vaccination of FcRn mice with very low dose of VSV prior to infection similarly prevented death after infection. In conclusion we determined the importance of nAbs during VSV infection. Lack of FcRn limited nAbs and thereby enhanced the susceptibility to virus infection.

A Dye-Sensitized Sensor for Oxygen Detection under Visible Light.

Sensors that can accurately assess oxygen (O2) concentrations in real time are crucial for a wide range of applications spanning personal health monitoring, environmental protection, and industrial process development. Here a high-performance chemiresistive sensor that allows for the rapid detection of O2 at room temperature under visible light illumination is described. Inspired by the operating principles of dye-sensitized solar cells, the chemiresistor is based on a single-walled carbon nanotube-titania hybrid (SWCNT-TiO2) bearing a molecular Re-based photosensitizer [(Pbpy)(CO)3ReBr] (Pbpy = 4,4'-[P(O)(OH)2]2-2,2'-bipyridine). The resulting SWCNT-TiO2-Re composite undergoes photoinduced charge transfer that is sensitive to ppb levels of O2, thereby yielding a rapid and reversible chemiresistive response. Owing to its unique mode of operation and robust components, the sensor shows a high degree of selectivity for O2 over a range of interferants, humidity tolerance, and multimonth benchtop stability. The approach presented herein demonstrates the translatability of concepts in light harvesting to the development of robust, rapid, and low-power sensing technologies.

Workflow interruptions and employee work outcomes: The moderating role of polychronicity.

Workflow interruptions are one of the most commonly experienced stressors at work. This research expands existing literature on workflow interruptions in a diary field study. We apply a within-person approach and investigate detrimental effects of daily workflow interruptions on both daily satisfaction with performance and daily emotional exhaustion. Furthermore, we introduce polychronicity (the trait-like preference of a person to deal with several activities at the same time) as a buffering factor in this relationship. Results of the diary study with knowledge workers over 5 consecutive working days (N = 149, 644 daily observations) showed that on days on which participants experienced a large amount of workflow interruptions, they reported lower levels of satisfaction with their performance and higher levels of emotional exhaustion on that same day. Polychronicity failed to moderate the positive association between interruptions and emotional exhaustion. However, polychronicity significantly moderated the negative association between daily interruptions and daily satisfaction with participants' own performance in a way that for people ranking high on polychronicity this negative association was dissolved. (PsycINFO Database Record