1.
Org Lett
; 24(43): 7924-7927, 2022 11 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36265082
RESUMO
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.