Detalhe da pesquisa
1.
Pazopanib for severe bleeding and transfusion-dependent anemia in hereditary hemorrhagic telangiectasia.
Angiogenesis
; 25(1): 87-97, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34292451
2.
Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo.
J Pharmacol Exp Ther
; 376(3): 436-443, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33376150
3.
Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia.
Angiogenesis
; 22(1): 145-155, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30191360
4.
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
Lancet
; 384(9949): 1187-95, 2014 Sep 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24930728
5.
Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers.
Br J Clin Pharmacol
; 76(1): 99-106, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23215699
6.
Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.
Arterioscler Thromb Vasc Biol
; 32(9): 2289-94, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22814748
7.
Apolipoprotein B-100-containing lipoprotein metabolism in subjects with lipoprotein lipase gene mutations.
Arterioscler Thromb Vasc Biol
; 32(2): 459-66, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22095987
8.
Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury.
Naunyn Schmiedebergs Arch Pharmacol
; 2023 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37966569
9.
Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.
Circulation
; 123(5): 515-23, 2011 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-21262998
10.
The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale.
Am Heart J
; 164(5): 646-653.e3, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23137494
11.
Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans.
Arterioscler Thromb Vasc Biol
; 30(11): 2256-63, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20689074
12.
Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial.
Eur J Heart Fail
; 22(9): 1641-1645, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32227554
13.
Assessing the Impact of Losmapimod on Proteinuria in Idiopathic Focal Segmental Glomerulosclerosis.
Kidney Int Rep
; 5(8): 1228-1239, 2020 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-32775822
14.
Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro.
J Lipid Res
; 50(11): 2222-34, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19282272
15.
Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
Am J Cardiovasc Drugs
; 19(3): 335-342, 2019 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-30637626
16.
A Randomized, Placebo-Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High-Density Lipoprotein Cholesterol in Subjects With Dyslipidemia.
Clin Pharmacol Drug Dev
; 8(7): 871-883, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31268250
17.
The Burden of Congestion in Patients Hospitalized With Acute Decompensated Heart Failure.
Am J Cardiol
; 124(4): 545-553, 2019 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31208702
18.
Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney disease.
Am J Cardiol
; 101(12): 1741-6, 2008 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18549850
19.
Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.
Arterioscler Thromb Vasc Biol
; 27(2): 359-65, 2007 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17110604
20.
Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta.
Am J Cardiol
; 100(11 A): n20-4, 2007 Dec 03.
Artigo
Inglês
| MEDLINE | ID: mdl-18047848