Detalhe da pesquisa
1.
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Bioorg Med Chem Lett
; 30(23): 127602, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33038544
2.
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Bioorg Med Chem Lett
; 30(12): 127205, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32336498
3.
3-Substituted Quinolines as RORγt Inverse Agonists.
Bioorg Med Chem Lett
; 29(12): 1463-1470, 2019 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31010722
4.
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
J Biol Chem
; 292(43): 17963-17974, 2017 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28860188
5.
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Bioorg Med Chem Lett
; 28(9): 1446-1455, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29631962
6.
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.
Bioorg Med Chem Lett
; 27(9): 2047-2057, 2017 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28318945
7.
6-Substituted quinolines as RORγt inverse agonists.
Bioorg Med Chem Lett
; 27(23): 5277-5283, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29079472
8.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
J Med Chem
; 65(15): 10419-10440, 2022 08 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35862732
9.
Rational design and synthesis of aminopiperazinones as ß-secretase (BACE) inhibitors.
Bioorg Med Chem Lett
; 21(24): 7255-60, 2011 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22071305
10.
Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds.
J Steroid Biochem Mol Biol
; 108(1-2): 44-54, 2008 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-17964775
11.
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
Bioorg Med Chem Lett
; 18(6): 2114-21, 2008 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18272363
12.
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Bioorg Med Chem Lett
; 18(9): 2865-70, 2008 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18420408
13.
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Structure
; 24(4): 502-508, 2016 Apr 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27050687
14.
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.
J Med Chem
; 48(4): 909-12, 2005 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-15715460
15.
Fragment screening purely with protein crystallography.
Methods Enzymol
; 493: 321-56, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21371597
16.
Potency variation of small-molecule chymase inhibitors across species.
Biochem Pharmacol
; 80(7): 1033-41, 2010 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20599788
17.
Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
J Med Chem
; 53(4): 1843-56, 2010 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20102150
18.
Structural basis for elastolytic substrate specificity in rodent alpha-chymases.
J Biol Chem
; 283(1): 427-436, 2008 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-17981788
19.
2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors.
Bioorg Med Chem Lett
; 17(22): 6266-9, 2007 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17889527
20.
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
J Biol Chem
; 282(6): 4094-101, 2007 Feb 09.
Artigo
Inglês
| MEDLINE | ID: mdl-17132624