Detalhe da pesquisa
1.
Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 27(4): 855-861, 2017 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28108251
2.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33214829
3.
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
J Med Chem
; 62(21): 9931-9946, 2019 11 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31638797
4.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem
; 60(12): 5193-5208, 2017 06 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28541707
5.
Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.
J Med Chem
; 59(21): 9837-9854, 2016 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27726358