RESUMO
Splenic rupture most commonly follows blunt abdominal trauma. Nontraumatic rupture of the spleen is rare. Nontraumatic rupture of the spleen has been described in a variety of pathologic conditions, which include neoplastic, infectious, and hematologic diseases affecting the spleen. Spontaneous rupture of nondiseased spleen is extremely rare. We report a case of spontaneous rupture of spleen in a chronic alcoholic clinically simulating acute pancreatitis.
Assuntos
Ruptura Esplênica/diagnóstico , Consumo Excessivo de Bebidas Alcoólicas/complicações , Diagnóstico Diferencial , Diagnóstico por Imagem , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Pancreatite/diagnóstico , Ruptura EspontâneaRESUMO
A novel series of quinolinone-based adenosine A(2B) receptor antagonists was identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogs highlighted essential structural features of the initial hit. Optimization resulted in an A(2B) antagonist (2i) which exhibited potent activity in a cAMP accumulation assay (5.1 nM) and an IL-8 release assay (0.4 nM).