Detalhe da pesquisa
1.
LUF7244 plus Dofetilide Rescues Aberrant Kv11.1 Trafficking and Produces Functional IKv11.1.
Mol Pharmacol
; 97(6): 355-364, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32241959
2.
Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574.
J Chem Inf Model
; 60(1): 360-371, 2020 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31877041
3.
Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents.
J Cell Mol Med
; 23(8): 4962-4969, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31119887
4.
Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
J Biol Chem
; 292(42): 17387-17398, 2017 10 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28842488
5.
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.
Cell Physiol Biochem
; 45(6): 2233-2245, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29550817
6.
Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.
Pharmacol Res
; 131: 150-163, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29477480
7.
Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.
Mol Pharmacol
; 92(4): 437-450, 2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28705808
8.
Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations.
Biochem Biophys Res Commun
; 484(1): 107-112, 2017 02 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28109880
9.
PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.
J Biomed Sci
; 24(1): 44, 2017 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28711067
10.
Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.
J Biol Chem
; 289(31): 21770-81, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24947510
11.
Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations.
PLoS Comput Biol
; 10(7): e1003746, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25079564
12.
Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.
J Chem Inf Model
; 55(4): 814-22, 2015 Apr 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25794351
13.
Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).
Biochem Biophys Res Commun
; 452(4): 992-7, 2014 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-25223803
14.
Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.
J Pharmacol Exp Ther
; 348(2): 346-58, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24307198
15.
Probing the energy landscape of activation gating of the bacterial potassium channel KcsA.
PLoS Comput Biol
; 9(5): e1003058, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23658510
16.
Structural insights into trapping and dissociation of small molecules in K⺠channels.
J Chem Inf Model
; 54(11): 3218-28, 2014 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-25297379
17.
In silico models of the macromolecular NaV1.5-KIR2.1 complex.
Front Physiol
; 15: 1362964, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38468705
18.
ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.
Mol Pharmacol
; 83(4): 805-13, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23319419
19.
Distinct interactions of Na+ and Ca2+ ions with the selectivity filter of the bacterial sodium channel Na(V)Ab.
Biochem Biophys Res Commun
; 430(4): 1272-6, 2013 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-23261433
20.
Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate.
Front Mol Biosci
; 10: 1137368, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36911523