Detalhe da pesquisa
1.
Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry.
Proc Natl Acad Sci U S A
; 116(42): 21001-21011, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31578253
2.
Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments.
Bioorg Med Chem Lett
; 29(1): 36-39, 2019 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30455147
3.
UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN.
J Biol Chem
; 292(40): 16539-16553, 2017 10 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28710279
4.
Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers.
Biochemistry
; 54(29): 4411-4, 2015 Jul 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26161728
5.
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.
J Am Chem Soc
; 137(39): 12442-5, 2015 Oct 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26371805
6.
Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways.
J Am Chem Soc
; 135(45): 16948-62, 2013 Nov 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24138456
7.
The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles.
Org Biomol Chem
; 11(18): 2932-5, 2013 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23536160
8.
Inhibiting protein synthesis to treat malaria.
Science
; 376(6597): 1049-1050, 2022 06 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35653471
9.
Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.
ACS Chem Biol
; 15(4): 1036-1049, 2020 04 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32149490
10.
Methodology for Identification of Cysteine-Reactive Covalent Inhibitors.
Methods Mol Biol
; 1967: 245-262, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31069775
11.
Monitoring PARKIN RBR Ubiquitin Ligase Activation States with UbFluor.
Curr Protoc Chem Biol
; 10(3): e45, 2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30063295
12.
Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis.
ChemMedChem
; 13(19): 2014-2023, 2018 10 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30028574
13.
UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis.
Curr Protoc Chem Biol
; 9(1): 11-37, 2017 03 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28253433
14.
High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor.
Curr Protoc Chem Biol
; 9(3): 174-195, 2017 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28910856
15.
Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.
Structure
; 25(7): 1120-1129.e3, 2017 07 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28578874
16.
Covalent Tethering of Fragments For Covalent Probe Discovery.
Medchemcomm
; 7(4): 576-585, 2016 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27398190
17.
Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis.
Chem Commun (Camb)
; 52(12): 2477-80, 2016 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26575161
18.
UbFluor: A Mechanism-Based Probe for HECT E3 Ligases.
Chem Sci
; 7(8): 5587-5595, 2016 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27482366
19.
An inhibitor of ubiquitin conjugation and aggresome formation.
Chem Sci
; 6(9): 5235-5245, 2015 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28717502
20.
Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes.
Chem Sci
; 6(3): 1770-1779, 2015 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28706640