Detalhe da pesquisa
1.
Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
J Neurosci
; 34(28): 9222-34, 2014 Jul 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25009256
2.
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP ßCTF.
Sci Adv
; 9(30): eadg1925, 2023 07 28.
Artigo
Inglês
| MEDLINE | ID: mdl-37494443
3.
Autophagy is a novel pathway for neurofilament protein degradation in vivo.
Autophagy
; 19(4): 1277-1292, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36131358
4.
Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.
Nat Commun
; 13(1): 5308, 2022 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36130946
5.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Cell Rep
; 33(8): 108420, 2020 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33238112
6.
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
J Neurosci
; 28(47): 12241-54, 2008 Nov 19.
Artigo
Inglês
| MEDLINE | ID: mdl-19020018