1.
Angew Chem Int Ed Engl
; 46(26): 5011-4, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17516601
2.
J Org Chem
; 69(4): 1097-103, 2004 Feb 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14961657
RESUMO
1,1,4,7,10,10-Hexamethyltriethylenetetramine (HMTTA) emerged from a limited parallel screening of selected polyamines as the most appropriate additive for an especially problematic Koenigs-Knorr glucuronidation. This initial finding rapidly evolved into a reliable and high-yielding procedure through the use of two sets of experimental designs. The detailed effect of the stoichiometry of reagents and the amount of amine additive on reaction yield was elucidated. The complexity of the response surface for product yield, described by a third-order polynomial equation, together with ancillary kinetic experiments evidenced the multiple role of HMTTA in the present glucuronidation process.