Effects of Stimulus Type on 16-kHz Detection Thresholds.

OBJECTIVES: Audiometric testing typically does not include frequencies above 8 kHz. However, recent research suggests that extended high-frequency (EHF) sensitivity could affect hearing in natural communication environments. Clinical assessment of hearing often employs pure tones and frequency-modulated (FM) tones interchangeably regardless of frequency. The present study was designed to evaluate how the stimulus chosen to measure EHF thresholds affects estimates of hearing sensitivity. DESIGN: The first experiment used standard audiometric procedures to measure 8- and 16-kHz thresholds for 5- to 28-year olds with normal hearing in the standard audiometric range (250 to 8000 Hz). Stimuli were steady tones, pulsed tones, and FM tones. The second experiment tested 18- to 28-year olds with normal hearing in the standard audiometric range using psychophysical procedures to evaluate how changes in sensitivity as a function of frequency affect detection of stimuli that differ with respect to bandwidth, including bands of noise. Thresholds were measured using steady tones, pulsed tones, FM tones, narrow bands of noise, and one-third-octave bands of noise at a range of center frequencies in one ear. RESULTS: In experiment 1, thresholds improved with increasing age at 8 kHz and worsened with increasing age at 16 kHz. Thresholds for individual participants were relatively similar for steady, pulsed, and FM tones at 8 kHz. At 16 kHz, mean thresholds were approximately 5 dB lower for FM tones than for steady or pulsed tones. This stimulus effect did not differ as a function of age. Experiment 2 replicated this greater stimulus effect at 16 kHz than at 8 kHz and showed that the slope of the audibility curve accounted for these effects. CONCLUSIONS: Contrary to prior expectations, there was no evidence that the choice of stimulus type affected school-age children more than adults. For individual participants, audiometric thresholds at 16 kHz were as much as 20 dB lower for FM tones than for steady tones. Threshold differences across stimuli at 16 kHz were predicted by differences in audibility across frequency, which can vary markedly between listeners. These results highlight the importance of considering spectral width of the stimulus used to evaluate EHF thresholds.

Sound Level Changes the Auditory Cortical Activation Detected with Functional Near-Infrared Spectroscopy.

BACKGROUND: Functional near-infrared spectroscopy (fNIRS) is a viable non-invasive technique for functional neuroimaging in the cochlear implant (CI) population; however, the effects of acoustic stimulus features on the fNIRS signal have not been thoroughly examined. This study examined the effect of stimulus level on fNIRS responses in adults with normal hearing or bilateral CIs. We hypothesized that fNIRS responses would correlate with both stimulus level and subjective loudness ratings, but that the correlation would be weaker with CIs due to the compression of acoustic input to electric output. METHODS: Thirteen adults with bilateral CIs and 16 with normal hearing (NH) completed the study. Signal-correlated noise, a speech-shaped noise modulated by the temporal envelope of speech stimuli, was used to determine the effect of stimulus level in an unintelligible speech-like stimulus between the range of soft to loud speech. Cortical activity in the left hemisphere was recorded. RESULTS: Results indicated a positive correlation of cortical activation in the left superior temporal gyrus with stimulus level in both NH and CI listeners with an additional correlation between cortical activity and perceived loudness for the CI group. The results are consistent with the literature and our hypothesis. CONCLUSIONS: These results support the potential of fNIRS to examine auditory stimulus level effects at a group level and the importance of controlling for stimulus level and loudness in speech recognition studies. Further research is needed to better understand cortical activation patterns for speech recognition as a function of both stimulus presentation level and perceived loudness.

Spectral weighting functions for localization of complex sound. II. The effect of competing noise.

Spectral weighting of sound localization cues was measured in the presence of three levels of competing noise presented in the free field. Target stimuli were complex tones containing seven tonal components, presented from an ∼120° range of frontal azimuths. Competitors were two independent Gaussian noises presented from 90° left and right azimuth at one of three levels yielding +9, 0, and -6 dB signal-to-noise ratio. Results revealed the greatest perceptual weight for components within the interaural time difference (ITD) "dominance region," which was found previously to peak around the 800-Hz component in quiet [Folkerts and Stecker (2022) J. Acoust. Soc. Am. 151, 3409-3425]. Here, peak weights were shifted toward lower-frequency components (i.e., 400 Hz) in all competing noise conditions. These results contradict the hypothesis of a shift in the peak weights toward higher frequencies based on previous behavioral localization performance in competing noise but are consistent with binaural cue sensitivity, availability, and reliability; measured low-frequency ITD cues within the dominance region were least disrupted by the presence of competing noise.

Spectral weighting functions for lateralization and localization of complex sound.

Perceptual weighting of sound localization cues across spectral components was measured over headphones [experiment (expt.) 1] and in the free field (expt. 2) and quantified in the form of spectral weighting functions (SWFs). Stimuli consisted of five complex sounds (conditions), each containing seven frequency components. Participants judged the spatial position of the stimuli with spatial cues varying across frequency components. In separate experiments, free-field stimuli were presented anechoically (expt. 2), in the presence of simulated reverberation (expt. 3), or with stimuli varying in level either corrected for equal loudness (expt. 4.1) or sloped by ±6 dB per component (expt. 4.2). Overall results revealed greatest weight in the vicinity of 800 Hz, for both localization and interaural time difference (ITD)-based lateralization, although specific features of the SWFs did vary across stimulus conditions. The shape of the SWF follows the pattern of ITD sensitivity across frequency and is consistent with previous descriptions of an ITD "dominance region" peaking around 600-800 Hz. The close similarity of free field and ITD-based SWFs is further consistent with the hypothesized dominant role of low-frequency ITD in localization of broadband sounds. Other conditions revealed relatively modest effects of reverberation and component level.

FORUM: Remote testing for psychological and physiological acoustics.

Acoustics research involving human participants typically takes place in specialized laboratory settings. Listening studies, for example, may present controlled sounds using calibrated transducers in sound-attenuating or anechoic chambers. In contrast, remote testing takes place outside of the laboratory in everyday settings (e.g., participants' homes). Remote testing could provide greater access to participants, larger sample sizes, and opportunities to characterize performance in typical listening environments at the cost of reduced control of environmental conditions, less precise calibration, and inconsistency in attentional state and/or response behaviors from relatively smaller sample sizes and unintuitive experimental tasks. The Acoustical Society of America Technical Committee on Psychological and Physiological Acoustics launched the Task Force on Remote Testing (https://tcppasa.org/remotetesting/) in May 2020 with goals of surveying approaches and platforms available to support remote testing and identifying challenges and considerations for prospective investigators. The results of this task force survey were made available online in the form of a set of Wiki pages and summarized in this report. This report outlines the state-of-the-art of remote testing in auditory-related research as of August 2021, which is based on the Wiki and a literature search of papers published in this area since 2020, and provides three case studies to demonstrate feasibility during practice.

Evidence for cue-independent spatial representation in the human auditory cortex during active listening.

Few auditory functions are as important or as universal as the capacity for auditory spatial awareness (e.g., sound localization). That ability relies on sensitivity to acoustical cues-particularly interaural time and level differences (ITD and ILD)-that correlate with sound-source locations. Under nonspatial listening conditions, cortical sensitivity to ITD and ILD takes the form of broad contralaterally dominated response functions. It is unknown, however, whether that sensitivity reflects representations of the specific physical cues or a higher-order representation of auditory space (i.e., integrated cue processing), nor is it known whether responses to spatial cues are modulated by active spatial listening. To investigate, sensitivity to parametrically varied ITD or ILD cues was measured using fMRI during spatial and nonspatial listening tasks. Task type varied across blocks where targets were presented in one of three dimensions: auditory location, pitch, or visual brightness. Task effects were localized primarily to lateral posterior superior temporal gyrus (pSTG) and modulated binaural-cue response functions differently in the two hemispheres. Active spatial listening (location tasks) enhanced both contralateral and ipsilateral responses in the right hemisphere but maintained or enhanced contralateral dominance in the left hemisphere. Two observations suggest integrated processing of ITD and ILD. First, overlapping regions in medial pSTG exhibited significant sensitivity to both cues. Second, successful classification of multivoxel patterns was observed for both cue types and-critically-for cross-cue classification. Together, these results suggest a higher-order representation of auditory space in the human auditory cortex that at least partly integrates the specific underlying cues.

Binaural spatial adaptation as a mechanism for asymmetric trading of interaural time and level differences.

A classic paradigm used to quantify the perceptual weighting of binaural spatial cues requires a listener to adjust the value of one cue, while the complementary cue is held constant. Adjustments are made until the auditory percept appears centered in the head, and the values of both cues are recorded as a trading relation (TR), most commonly in µs interaural time difference per dB interaural level difference. Interestingly, existing literature has shown that TRs differ according to the cue being adjusted. The current study investigated whether cue-specific adaptation, which might arise due to the continuous, alternating presentation of signals during adjustment tasks, could account for this poorly understood phenomenon. Three experiments measured TRs via adjustment and via lateralization of single targets in virtual reality (VR). Targets were 500 Hz pure tones preceded by silence or by adapting trains that held one of the cues constant. VR removed visual anchors and provided an intuitive response technique during lateralization. The pattern of results suggests that adaptation can account for cue-dependent TRs. In addition, VR seems to be a viable tool for psychophysical tasks.

Binaural interference with simulated electric acoustic stimulation.

Preserved low-frequency acoustic hearing in cochlear implant (CI) recipients affords combined electric-acoustic stimulation (EAS) that could improve access to low-frequency acoustic binaural cues and enhance spatial hearing. Such benefits, however, could be undermined by interactions between electrical and acoustical inputs to adjacent (spectral overlap) or distant (binaural interference) cochlear places in EAS. This study simulated EAS in normal-hearing listeners, measuring interaural time difference (ITD) and interaural level difference (ILD) discrimination thresholds for a low-frequency noise (simulated acoustic target) in the presence or absence of a pulsatile high-frequency complex presented monotically or diotically (simulated unilateral or bilateral electric distractor). Unilateral distractors impaired thresholds for both cue types, suggesting influences of both binaural interference (which appeared more consistently for ITD than ILD) and physical spectral overlap (for both cue types). Reducing spectral overlap with an EAS gap between 1 and 3 kHz consistently improved binaural sensitivity. Finally, listeners displayed significantly lower thresholds with simulated bilateral versus unilateral electric stimulation. The combined effects revealed similar or better thresholds in bilateral full spectral overlap than in unilateral EAS gap conditions, suggesting that bilateral implantation with bilateral acoustic hearing preservation could allow for higher tolerance of spectral overlap in CI users and improved binaural sensitivity over unilateral EAS.

Temporal weighting functions for interaural time and level differences. V. Modulated noise carriers.

Sound onsets dominate spatial judgments of many types of periodic sound. Conversely, ongoing cues often dominate in spatial judgments of aperiodic noise. This study quantified onset dominance as a function of both the bandwidth and the temporal regularity of stimuli by measuring temporal weighting functions (TWF) from Stecker, Ostreicher, and Brown [(2013) J. Acoust. Soc. Am. 134, 1242-1252] for lateralization of periodic and aperiodic noise-burst trains. Stimuli consisted of 16 noise bursts (1 ms each) repeating at an interval of 2 or 5 ms. TWFs were calculated by multiple regression of lateralization judgments onto interaural time and level differences, which varied independently ( ±100 µs, ±2 dB) across bursts. Noise tokens were either refreshed on each burst (aperiodic) or repeated across sets of 2, 4, 8, or 16 bursts. TWFs revealed strong onset dominance for periodic noise-burst trains (16 repeats per token), which was markedly reduced in aperiodic trains. A second experiment measured TWFs for periodic but sinusoidally amplitude-modulated noise burst trains, revealing greater weight on the earliest and least intense bursts of the rising envelope slope. The results support the view that envelope fluctuations drive access to binaural information in both periodic and aperiodic sounds.

Reverberation enhances onset dominance in sound localization.

Temporal variation in sensitivity to sound-localization cues was measured in anechoic conditions and in simulated reverberation using the temporal weighting function (TWF) paradigm [Stecker and Hafter (2002). J. Acoust. Soc. Am. 112, 1046-1057]. Listeners judged the locations of Gabor click trains (4 kHz center frequency, 5-ms interclick interval) presented from an array of loudspeakers spanning 360° azimuth. Targets ranged ±56.25° across trials. Individual clicks within each train varied by an additional ±11.25° to allow TWF calculation by multiple regression. In separate conditions, sounds were presented directly or in the presence of simulated reverberation: 13 orders of lateral reflection were computed for a 10 m × 10 m room ( RT60≊300 ms) and mapped to the appropriate locations in the loudspeaker array. Results reveal a marked increase in perceptual weight applied to the initial click in reverberation, along with a reduction in the impact of late-arriving sound. In a second experiment, target stimuli were preceded by trains of "conditioner" sounds with or without reverberation. Effects were modest and limited to the first few clicks in a train, suggesting that impacts of reverberant pre-exposure on localization may be limited to the processing of information from early reflections.

Spectrotemporal weighting of binaural cues: Effects of a diotic interferer on discrimination of dynamic interaural differences.

Spatial judgments are often dominated by low-frequency binaural cues and onset cues when binaural cues vary across the spectrum and duration, respectively, of a brief sound. This study combined these dimensions to assess the spectrotemporal weighting of binaural information. Listeners discriminated target interaural time difference (ITD) and interaural level difference (ILD) carried by the onset, offset, or full duration of a 4-kHz Gabor click train with a 2-ms period in the presence or absence of a diotic 500-Hz interferer tone. ITD and ILD thresholds were significantly elevated by the interferer in all conditions and by a similar amount to previous reports for static cues. Binaural interference was dramatically greater for ITD targets lacking onset cues compared to onset and full-duration conditions. Binaural interference for ILD targets was similar across dynamic-cue conditions. These effects mirror the baseline discriminability of dynamic ITD and ILD cues [Stecker and Brown. (2010). J. Acoust. Soc. Am. 127, 3092-3103], consistent with stronger interference for less-robust/higher-variance cues. The results support the view that binaural cue integration occurs simultaneously across multiple variance-weighted dimensions, including time and frequency.

Monaural and binaural contributions to interaural-level-difference sensitivity in human auditory cortex.

Whole-brain functional magnetic resonance imaging was used to measure blood-oxygenation-level-dependent (BOLD) responses in human auditory cortex (AC) to sounds with intensity varying independently in the left and right ears. Echoplanar images were acquired at 3 Tesla with sparse image acquisition once per 12-second block of sound stimulation. Combinations of binaural intensity and stimulus presentation rate were varied between blocks, and selected to allow measurement of response-intensity functions in three configurations: monaural 55-85 dB SPL, binaural 55-85 dB SPL with intensity equal in both ears, and binaural with average binaural level of 70 dB SPL and interaural level differences (ILD) ranging ±30 dB (i.e., favoring the left or right ear). Comparison of response functions equated for contralateral intensity revealed that BOLD-response magnitudes (1) generally increased with contralateral intensity, consistent with positive drive of the BOLD response by the contralateral ear, (2) were larger for contralateral monaural stimulation than for binaural stimulation, consistent with negative effects (e.g., inhibition) of ipsilateral input, which were strongest in the left hemisphere, and (3) also increased with ipsilateral intensity when contralateral input was weak, consistent with additional, positive, effects of ipsilateral stimulation. Hemispheric asymmetries in the spatial extent and overall magnitude of BOLD responses were generally consistent with previous studies demonstrating greater bilaterality of responses in the right hemisphere and stricter contralaterality in the left hemisphere. Finally, comparison of responses to fast (40/s) and slow (5/s) stimulus presentation rates revealed significant rate-dependent adaptation of the BOLD response that varied across ILD values.

Population receptive field estimates of human auditory cortex.

Here we describe a method for measuring tonotopic maps and estimating bandwidth for voxels in human primary auditory cortex (PAC) using a modification of the population Receptive Field (pRF) model, developed for retinotopic mapping in visual cortex by Dumoulin and Wandell (2008). The pRF method reliably estimates tonotopic maps in the presence of acoustic scanner noise, and has two advantages over phase-encoding techniques. First, the stimulus design is flexible and need not be a frequency progression, thereby reducing biases due to habituation, expectation, and estimation artifacts, as well as reducing the effects of spatio-temporal BOLD nonlinearities. Second, the pRF method can provide estimates of bandwidth as a function of frequency. We find that bandwidth estimates are narrower for voxels within the PAC than in surrounding auditory responsive regions (non-PAC).

Evidence for a neural source of the precedence effect in sound localization.

Normal-hearing human listeners and a variety of studied animal species localize sound sources accurately in reverberant environments by responding to the directional cues carried by the first-arriving sound rather than spurious cues carried by later-arriving reflections, which are not perceived discretely. This phenomenon is known as the precedence effect (PE) in sound localization. Despite decades of study, the biological basis of the PE remains unclear. Though the PE was once widely attributed to central processes such as synaptic inhibition in the auditory midbrain, a more recent hypothesis holds that the PE may arise essentially as a by-product of normal cochlear function. Here we evaluated the PE in a unique human patient population with demonstrated sensitivity to binaural information but without functional cochleae. Users of bilateral cochlear implants (CIs) were tested in a psychophysical task that assessed the number and location(s) of auditory images perceived for simulated source-echo (lead-lag) stimuli. A parallel experiment was conducted in a group of normal-hearing (NH) listeners. Key findings were as follows: 1) Subjects in both groups exhibited lead-lag fusion. 2) Fusion was marginally weaker in CI users than in NH listeners but could be augmented by systematically attenuating the amplitude of the lag stimulus to coarsely simulate adaptation observed in acoustically stimulated auditory nerve fibers. 3) Dominance of the lead in localization varied substantially among both NH and CI subjects but was evident in both groups. Taken together, data suggest that aspects of the PE can be elicited in CI users, who lack functional cochleae, thus suggesting that neural mechanisms are sufficient to produce the PE.

Temporal weighting of binaural information at low frequencies: Discrimination of dynamic interaural time and level differences.

The importance of sound onsets in binaural hearing has been addressed in many studies, particularly at high frequencies, where the onset of the envelope may carry much of the useful binaural information. Some studies suggest that sound onsets might play a similar role in the processing of binaural cues [e.g., fine-structure interaural time differences (ITD)] at low frequencies. This study measured listeners' sensitivity to ITD and interaural level differences (ILD) present in early (i.e., onset) and late parts of 80-ms pure tones of 250-, 500-, and 1000-Hz frequency. Following previous studies, tones carried static interaural cues or dynamic cues that peaked at sound onset and diminished to zero at sound offset or vice versa. Although better thresholds were observed in static than dynamic conditions overall, ITD discrimination was especially impaired, regardless of frequency, when cues were not available at sound onset. Results for ILD followed a similar pattern at 1000 Hz; at lower frequencies, ILD thresholds did not differ significantly between dynamic-cue conditions. The results support the "onset" hypothesis of Houtgast and Plomp [(1968). J. Acoust. Soc. Am. 44, 807-812] for ITD discrimination, but not necessarily ILD discrimination, in low-frequency pure tones.

Auditory motion processing after early blindness.

Studies showing that occipital cortex responds to auditory and tactile stimuli after early blindness are often interpreted as demonstrating that early blind subjects "see" auditory and tactile stimuli. However, it is not clear whether these occipital responses directly mediate the perception of auditory/tactile stimuli, or simply modulate or augment responses within other sensory areas. We used fMRI pattern classification to categorize the perceived direction of motion for both coherent and ambiguous auditory motion stimuli. In sighted individuals, perceived motion direction was accurately categorized based on neural responses within the planum temporale (PT) and right lateral occipital cortex (LOC). Within early blind individuals, auditory motion decisions for both stimuli were successfully categorized from responses within the human middle temporal complex (hMT+), but not the PT or right LOC. These findings suggest that early blind responses within hMT+ are associated with the perception of auditory motion, and that these responses in hMT+ may usurp some of the functions of nondeprived PT. Thus, our results provide further evidence that blind individuals do indeed "see" auditory motion.

Temporal weighting functions for interaural time and level differences. IV. Effects of carrier frequency.

Temporal variation in listeners' sensitivity to interaural time and level differences (ITD and ILD, respectively) was measured for sounds of different carrier frequency using the temporal weighting function (TWF) paradigm [Stecker and Hafter (2002) J. Acoust. Soc. Am. 112,1046-1057]. Listeners made lateralization judgments following brief trains of filtered impulses (Gabor clicks) presented over headphones with overall ITD and/or ILD ranging from ±500 µs ITD and/or ±5 dB ILD across trials. Individual clicks within each train varied by an additional ±100 µs ITD or ±2 dB ILD to allow TWF calculation by multiple regression. In separate conditions, TWFs were measured for carrier frequencies of 1, 2, 4, and 8 kHz. Consistent with past studies, TWFs demonstrated high weight on the first click for stimuli with short interclick interval (ICI = 2 ms), but flatter weighting for longer ICI (5-10 ms). Some conditions additionally demonstrated greater weight for clicks near the offset than near the middle of the train. Results support a primary role of the auditory periphery in emphasizing onset and offset cues in rapidly modulated low-frequency sounds. For slower modulations, sensitivity to ongoing high-frequency ILD and low-frequency ITD cues appears subject to recency effects consistent with the effects of leaky temporal integration of binaural information.

Nonuniform temporal weighting of interaural time differences in 500 Hz tones.

The discrimination and lateralization of interaural time differences (ITD) in rapidly modulated high-frequency sounds is dominated by cues present in the initial portion of the sound (i.e., at sound onset). The importance of initial ITD at low frequencies is, however, less clear. Here, ITD discrimination thresholds were measured in 500 Hz pure tones with diotic envelopes and static or dynamic fine-structure ITD. Static-ITD thresholds improved as tone duration increased from 40 to 640 ms but by an amount less than expected from uniform temporal weighting of binaural information. Dynamic conditions eliminated ITD from either the beginning or end of the sound by presenting slightly different frequencies to the two ears. While overall thresholds were lower when ITD was available at sound onset than when it was not, listeners differed appreciably in that regard. The results demonstrate that weighting of ITD is not temporally uniform. Instead, for many listeners, ITD discrimination at 500 Hz appears dominated by ITD cues present in the initial part of the sound. To a variable degree, other listeners rely more equally on ITD cues occurring near sound onsets and offsets, although no listeners appear to utilize such cues uniformly throughout the sound's duration.

The rapid decline in interaural-time-difference sensitivity for pure tones can be explained by peripheral filtering.

Purpose: The interaural time difference (ITD) is a primary horizontal-plane sound localization cue computed in the auditory brainstem. ITDs are accessible in the temporal fine structure of pure tones with a frequency of no higher than about 1400 Hz. Explaining how listeners' ITD sensitivity transitions from very best sensitivity near 700 Hz to impossible to detect within 1 octave currently lacks a fully compelling physiological explanation. Here, it was hypothesized that the rapid decline in ITD sensitivity is dictated not by a central neural limitation but by initial peripheral sound encoding, specifically, the low-frequency (apical) edge of the cochlear excitation pattern produced by a pure tone. Methods: ITD sensitivity was measured in 16 normal-hearing listeners as a joint function of frequency (900-1500 Hz) and level (10-50 dB sensation level). Results: Performance decreased with increasing frequency and decreasing sound level. The slope of performance decline was 90 dB/octave, consistent with the low-frequency slope of the cochlear excitation pattern. Conclusion: Fine-structure ITD sensitivity near 1400 Hz may be conveyed primarily by "off-frequency" activation of neurons tuned to lower frequencies near 700 Hz. Physiologically, this could be realized by having neurons sensitive to fine-structure ITD up to only about 700 Hz. A more extreme model would have only a single narrow channel near 700 Hz that conveys fine-structure ITDs. Such a model is a major simplification and departure from the classic formulation of the binaural display, which consists of a matrix of neurons tuned to a wide range of relevant frequencies and ITDs.