Detalhe da pesquisa
1.
Development of Cilofexor, an intestinally-biased Farnesoid X Receptor agonist, for the treatment of fatty liver disease.
J Pharmacol Exp Ther
; 2024 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38409114
2.
Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors.
Bioorg Med Chem Lett
; 33: 127744, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33333163
3.
Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold.
Bioorg Med Chem Lett
; 33: 127738, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33316404
4.
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Bioorg Med Chem Lett
; 30(12): 127205, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32336498
5.
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Bioorg Med Chem Lett
; 30(12): 127174, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32334912
6.
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Bioorg Med Chem Lett
; 28(9): 1446-1455, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29631962
7.
Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.
Bioorg Med Chem Lett
; 26(15): 3746-53, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27268696
8.
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Bioorg Med Chem Lett
; 20(16): 4911-7, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20638278
9.
Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.
ACS Med Chem Lett
; 11(2): 179-187, 2020 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32071686
10.
Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities.
Curr Top Med Chem
; 14(19): 2143-58, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25388536
11.
Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.
J Med Chem
; 55(2): 709-16, 2012 Jan 26.
Artigo
Inglês
| MEDLINE | ID: mdl-22175799
12.
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Arthritis Rheum
; 60(7): 2008-18, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19565489