Detalhe da pesquisa
1.
MutationExplorer: a webserver for mutation of proteins and 3D visualization of energetic impacts.
Nucleic Acids Res
; 2024 Apr 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38647044
2.
HSP70-binding motifs function as protein quality control degrons.
Cell Mol Life Sci
; 80(1): 32, 2023 Jan 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36609589
3.
Mapping the degradation pathway of a disease-linked aspartoacylase variant.
PLoS Genet
; 17(4): e1009539, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33914734
4.
Biophysical and Mechanistic Models for Disease-Causing Protein Variants.
Trends Biochem Sci
; 44(7): 575-588, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30712981
5.
Interpreting the molecular mechanisms of disease variants in human transmembrane proteins.
Biophys J
; 122(11): 2176-2191, 2023 06 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36600598
6.
Rare Catechol-O-methyltransferase Missense Variants Are Structurally Unstable Proteasome Targets.
Biochemistry
; 62(8): 1394-1405, 2023 04 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36976271
7.
Lynch syndrome, molecular mechanisms and variant classification.
Br J Cancer
; 128(5): 726-734, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36434153
8.
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system.
Biochem J
; 479(4): 479-501, 2022 02 17.
Artigo
Inglês
| MEDLINE | ID: mdl-35089310
9.
Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation.
PLoS Genet
; 16(11): e1009187, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33137092
10.
Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance.
Mol Biol Evol
; 38(8): 3235-3246, 2021 07 29.
Artigo
Inglês
| MEDLINE | ID: mdl-33779753
11.
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry.
Cell Mol Life Sci
; 78(5): 2263-2278, 2021 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-32936312
12.
Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations.
PLoS Genet
; 13(4): e1006739, 2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28422960
13.
Toward mechanistic models for genotype-phenotype correlations in phenylketonuria using protein stability calculations.
Hum Mutat
; 40(4): 444-457, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30648773
14.
Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition.
PLoS Genet
; 17(4): e1009496, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33886538
15.
Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants.
Biochemistry
; 57(41): 5957-5968, 2018 10 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30230310
16.
Blocking protein quality control to counter hereditary cancers.
Genes Chromosomes Cancer
; 56(12): 823-831, 2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28779490
17.
3did: a catalog of domain-based interactions of known three-dimensional structure.
Nucleic Acids Res
; 42(Database issue): D374-9, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24081580
18.
Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Proc Natl Acad Sci U S A
; 109(14): 5277-82, 2012 Apr 03.
Artigo
Inglês
| MEDLINE | ID: mdl-22403064
19.
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.
Genome Biol
; 25(1): 98, 2024 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38627865
20.
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants.
Nat Commun
; 15(1): 4026, 2024 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38740822