[A morphological assessment of the efficacy of benzofurocaine in experimental burns]. / Morfologicheskaia otsenka éffektivnosti benzofurokaina pri éksperimental'noi ozhogovoi bolezni.

Studies of the effect of benzophurocaine on the morphological structure of the skin and viscera in animals with burn disease have shown the drug to have a protective action. The latter one manifested itself in a considerable reduction of injuries to the viscera and in a more rapid recovery of the disordered structure and function.

[The characteristics of the analgesic action of nitrosorbide and no-shpa]. / Kharakteristika obezbolivaiushchego deistviia nirtosorbida i no shpy.

The study was conducted on experimental models of pain sense induced in mice by exposure to thermic or chemical factors and in rats by exposure to electric factors. Nitrosorbide and no-spa possess a dose-dependent analgesic effect. Both drugs excelled analgin in the intensity and duration of analgesic effect.

[Some features of the effect of voltaren on the coronary blood flow in patients with rheumatoid arthritis]. / Nekotorye osobennosti vliiania vol'tarena na koronarnyi krobotok u bol'nykh revmatoidnym artitom.

Electrocardiography and tetrapolar rheoplethysmography of the finger have demonstrated that voltaren and 5-NK activity produce an adverse action on the coronary blood flow in patients with rheumatoid arthritis. It has been found possible to correct the induced disorders by cordarone.

[The effect of euphylline on the antimicrobial activity of antibiotics]. / Vliianie éufillina na protivomikrobnuiu aktivnost' antibiotikov.

Antimicrobic properties of euphylline as well as its effects on antibacterial activity of penicillins, cephalosporins, and aminoglycosides were studied. It was established that euphylline differently affects antimicrobic activity of aforementioned drugs.

[Comparative evaluation of the wound-healing effect of benzofuracaine, etaden, and xanthinol nicotinate in an experiment]. / Sravnitel'naia otsenka ranozazhivliaiushchego deistviia benzofurokaina, étadena i ksantinola nikotinata v éksperimente.

The effect of benzofuracaine, etaden, and xanthinol nicotinate on the healing of skin wounds was studied in rat experiments. On days 1-14 of postmechanical injury, intramuscular benzofuracaine (15, 30, 60, and 120 mg/kg), etaden (20 mg/kg), and xanthinol nicotinate (each drug alone) reparative processes in the skin wounds developed more rapidly and processes of microcirculation in the region of the injury were normalized. The wound-healing effect of benzofurocaine in an ortimal dose of 60 mg/kg was more marked than that op etaden and xanthinol nicotinate. With benzofuracaine and etaden, the skin wounds healed completely by the 14th day of the experiment in 57% and 28.6% of animals, respectively. Such cases were not encountered among animals treated with xanthinol nicotinate and in the controls (untreated animals).

[Mechanism of the anti-inflammatory and analgesic effects of benzofurocaine and voltaren]. / K mekhanizmu protivovospalitel'nogo i boleutoliaiushchego éffektov benzofurokaina i vol'tarena.

Non-narcotic analgesics benzofurocaine and voltaren (10% of LD50) were shown to exert the protective effect on rats in castor oil-induced diarrhea, to decrease in mice the degree of pain reaction under the influence of acetylcholine, acetic acid and thermic stimulation.

[Method of evaluating the duration of spinal anesthesia in an experiment]. / Sposob otsenki prodolzhitel'nosti spinnomozgovoi anestezii v éksperimente.

A method for the evaluation of local anesthetics for spinal anesthesia according to changes in motor activity of hind limbs of the rat is proposed.

[Effects of benzofurocaine, etaden and xanthinol nicotinate on reparative bone regeneration in animal experiments]. / Vliianie benzofurokaina, étadena i ksantinola nikotinata na reparativnuiu regeneratsiiu kostei v éksperimente.

In the process of treatment of experimental close fractures of radius in rats by intramuscular administration of benzofurocaine (60 mg/kg), the regeneration processes of the bone tissue were activated to a greater degree than in case of administration of etadene (20 mg/kg) or xanthinol nicotinate (30 mg/kg). Under the influence of benzofurocaine, beginning on the 10-20-th day of the experiment, there have been noted the reorganization of young callus into the mature laminal bone. The preparations of comparison have demonstrated less expressed analogous action.

[Effect of nonsteroidal anti-inflammatory agents on the myocardial blood supply and oxygen regimen]. / Vliianie nesteroidnykh protivovospalitel'nykh sredstv na krovosnabzhenie i kislorodnyi rezhim miokarda.

Experiments on intact cats were made to study the effect of intravenous injection of voltaren (4 mg/kg) and intraventricular injection of indomethacin (4 mg/kg), ibuprophen (5 mg/kg), and butadion (22 mg/kg) on the coronary circulation and oxygen consumption by the myocardium. Indomethacin and butadion decreased the volumetric velocity of the coronary circulation and to a lesser degree oxygen consumption by the myocardium in all the experiments, whereas voltaren in 8 of 15 experiments. Ibuprophen and voltaren (in part of experiments) led to an increase in the coronary circulation and to greater oxygen utilization by the myocardium.

[Mechanism of action of voltaren on the smooth muscles of the blood vessels]. / Mekhanizm deistviia vol'tarena na gladkie myshtsy krovenosnykh sosudov.

The effect of voltaren on the electrical and contractile activity of smooth muscle cells of the rabbit portal vein and the bovine cerebral arteries was studied by sucrose gap method. Voltaren was found to rarefy (10(-6)-10-10(-3)mol/l) or to suppress (10(-4)-10(-3)mol/l) spontaneous electrical and contractile activity and to relax the portal vein muscle strips. At concentrations of 5.10(-6)-5.10(-3) mol/l voltaren caused a dose-dependent relaxation of the cerebral arterial muscle strips. The relaxation of the smooth muscles of the blood vessels induced by voltaren is suggested to be due to inhibition of calcium ions influx into muscle cells through different types of calcium channels.

[The effect of benzofurocaine on acute inflammation in rats and on the activity of prostaglandin synthetase in vitro]. / Vliianie benzofurokaina na ostroe vospalenie u krys i aktivnost' prostaglandinsintetazy in vitro.

Benzofurocaine similarly to ortophen (voltaren) causes dose-dependent suppression of acute inflammatory reactions induced in rats by carragheenin, serotonin and histamine, protects animals from absolutely lethal dose of cellulose sulphate. When administered in a dose of 0.79 X 10(-3) M, benzofurocaine exerts no effect on the activity of prostaglandin synthetase.

[Antioxidant properties of benzofurocaine, phenycaberan and orthophen]. / Antioksidantnye svoistva benzofurokaina, fenikaberana i ortofena.

The antioxidant properties of benzofurocaine, phenycaberan, crithophen, alpha-tocopherol and ionol were evaluated by inhibition of oxygen absorption by liposomes from egg phosphatidylcholine induced by the addition of an prooxidant. The activity of the tested agents at inhibition of Fe2+-ascorbater-initiated oxidation decreases in the order: ionol, benzofurocaine, phenycaberan, orthophen, alpha-tocopherol; emine-initiated (EDTA-independent) oxidation of phosphatidylcholine is inhibited only by ionol, orthophen and alpha-tocopherol. Phenycaberan exerts no effect on oxidation and benzofurocaine increases the rate of emine-initiated absorption of oxygen. Thus, benzofurocaine, phenycaberan and orthophen may be referred to as selective inhibitors of Fe2+-initiated peroxidation of phosphatidylcholine.

[Use of trental for correcting the pharmacological effects caused by voltaren and indomethacin]. / Primenenie trentala dlia korrektsii farmakologicheskikh éffektov, vyzvannykh vol'tarenom i indometatsinom.

Treatment of the adjuvant disease in rats by intragastric administration of voltaren or indomethacin (3 mg/kg) was followed by approximately equal anti-inflammatory and analgesic effects on the affected joints. In this case the development of active dystrophic changes in the gastrointestinal tract and kidneys was observed. At combined administration of the antiphlogistics with trental there was noted an enhancement of their therapeutic action on the joints and also a weakening of the ulcerogenic effect and nephrotoxicity that was reflected in the clinical, pathological, morphological and laboratory studies.