Detalhe da pesquisa
1.
Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach.
Bioorg Med Chem
; 100: 117633, 2024 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38342078
2.
Discovery of macrocyclic CDK2/4/6 inhibitors with improved potency and DMPK properties through a highly efficient macrocyclic drug design platform.
Bioorg Chem
; 146: 107285, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38547721
3.
Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair.
Nucleic Acids Res
; 47(7): 3536-3549, 2019 04 23.
Artigo
Inglês
| MEDLINE | ID: mdl-30698791
4.
Ultra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage.
Nucleic Acids Res
; 47(17): e100, 2019 09 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31318974
5.
Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.
Proc Natl Acad Sci U S A
; 115(19): E4368-E4376, 2018 05 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29632207
6.
C8-glycosphingolipids preferentially insert into tumor cell membranes and promote chemotherapeutic drug uptake.
Biochim Biophys Acta
; 1848(8): 1656-70, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25917957
7.
Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
PLoS Genet
; 9(4): e1003431, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23637614
8.
Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer.
J Med Chem
; 67(10): 8161-8171, 2024 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38690856
9.
Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.
J Mol Biol
; 436(2): 168383, 2024 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38070861
10.
DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II.
Nat Commun
; 13(1): 3624, 2022 06 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35750669
11.
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.
Nat Cell Biol
; 23(6): 608-619, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34108662
12.
WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin.
Cell Rep
; 33(9): 108469, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33264625
13.
Traveling Rocky Roads: The Consequences of Transcription-Blocking DNA Lesions on RNA Polymerase II.
J Mol Biol
; 429(21): 3146-3155, 2017 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-27851891
14.
Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.
Nat Cell Biol
; 23(7): 809, 2021 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-34163038