Detalhe da pesquisa
1.
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
Bioorg Med Chem
; 63: 116729, 2022 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35439688
2.
Development of autotaxin inhibitors: A series of tetrazole cinnamides.
Bioorg Med Chem Lett
; 31: 127663, 2021 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33160025
3.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.
Bioorg Med Chem
; 28(23): 115815, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33091850
4.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
J Med Chem
; 67(4): 3090-3111, 2024 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38306388
5.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J Med Chem
; 66(13): 9147-9160, 2023 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37395055
6.
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
J Med Chem
; 64(11): 7241-7260, 2021 06 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34028270