Detalhe da pesquisa
1.
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.
Cell
; 178(3): 748-761.e17, 2019 07 25.
Artigo
Inglês
| MEDLINE | ID: mdl-31280962
2.
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Cell
; 179(4): 895-908.e21, 2019 10 31.
Artigo
Inglês
| MEDLINE | ID: mdl-31675498
3.
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell
; 172(1-2): 55-67.e15, 2018 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-29307491
4.
GPCR-G Protein-ß-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Cell
; 166(4): 907-919, 2016 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27499021
5.
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.
Cell
; 178(4): 1030, 2019 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31398329
6.
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry
; 62(7): 1233-1248, 2023 04 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36917754
7.
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.
Nat Chem Biol
; 16(8): 841-849, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32367019
8.
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Nature
; 535(7612): 448-52, 2016 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-27409812
9.
Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
Proc Natl Acad Sci U S A
; 114(7): 1708-1713, 2017 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28130548
10.
Conformationally selective RNA aptamers allosterically modulate the ß2-adrenoceptor.
Nat Chem Biol
; 12(9): 709-16, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27398998
11.
A stress response pathway regulates DNA damage through ß2-adrenoreceptors and ß-arrestin-1.
Nature
; 477(7364): 349-53, 2011 Aug 21.
Artigo
Inglês
| MEDLINE | ID: mdl-21857681
12.
Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.
Circulation
; 131(24): 2120-30, 2015 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25995315
13.
Allosteric modulation of ß-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
J Biol Chem
; 289(41): 28271-83, 2014 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-25170081
14.
Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).
J Biol Chem
; 289(20): 14211-24, 2014 May 16.
Artigo
Inglês
| MEDLINE | ID: mdl-24668815
15.
Regulation of ß2-adrenergic receptor function by conformationally selective single-domain intrabodies.
Mol Pharmacol
; 85(3): 472-81, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24319111
16.
Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.
Proc Natl Acad Sci U S A
; 106(46): 19575-80, 2009 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-19889983
17.
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.
J Med Chem
; 65(5): 4201-4217, 2022 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35195401
18.
p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.
Biochemistry
; 49(12): 2657-71, 2010 Mar 30.
Artigo
Inglês
| MEDLINE | ID: mdl-20136148
19.
Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.
Mol Pharmacol
; 77(3): 327-38, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19933401
20.
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Trends Pharmacol Sci
; 39(8): 748-765, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29885909