Detalhe da pesquisa
1.
Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
J Nat Prod
; 83(4): 937-954, 2020 04 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32196334
2.
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.
Bioorg Med Chem Lett
; 27(5): 1304-1310, 2017 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28117205
3.
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Bioorg Med Chem
; 24(5): 938-956, 2016 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26852340
4.
Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.
Bioorg Med Chem
; 23(24): 7497-520, 2015 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26775540
5.
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.
Bioorg Med Chem
; 23(21): 6974-92, 2015 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26462052
6.
Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3â³,4â³,5â³-trimethoxybenzoyl)-6-methoxyindole (OXi8006).
Bioorg Med Chem
; 21(21): 6831-43, 2013 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23993969
7.
Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.
Bioorg Med Chem
; 21(24): 8019-32, 2013 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24183586
8.
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
J Nat Prod
; 76(9): 1668-78, 2013 Sep 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24016002
9.
Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1.
J Nat Prod
; 74(7): 1568-74, 2011 Jul 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21718055
10.
Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.
Bioorg Med Chem Lett
; 20(22): 6610-5, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20933415
11.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.
Bioorg Med Chem Lett
; 20(4): 1415-9, 2010 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20089402
12.
Regio- and stereospecific synthesis of mono-beta-d-glucuronic acid derivatives of combretastatin A-1.
J Nat Prod
; 73(6): 1093-101, 2010 Jun 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20496923
13.
Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents.
Bioorg Med Chem
; 17(19): 6993-7001, 2009 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19733085
14.
Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.
Medchemcomm
; 10(8): 1445-1456, 2019 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31534659
15.
Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.
J Med Chem
; 62(11): 5594-5615, 2019 06 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31059248
16.
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Bioorg Med Chem Lett
; 18(18): 5146-9, 2008 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18710804
17.
Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
Bioorg Med Chem
; 16(17): 8161-71, 2008 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18722127
18.
Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross.
Cancer Res
; 66(15): 7793-800, 2006 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16885383
19.
Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
Medchemcomm
; 9(10): 1649-1662, 2018 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30429970
20.
Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains.
Genetics
; 169(4): 2189-97, 2005 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-15687265