Detalhe da pesquisa
1.
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells.
Science
; 384(6694): eadk5864, 2024 Apr 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38662832
2.
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.
J Med Chem
; 65(1): 757-784, 2022 01 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34967602
3.
The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase.
Bioorg Med Chem Lett
; 20(6): 1994-2000, 2010 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20167488
4.
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
Eur J Med Chem
; 145: 606-621, 2018 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29348070
5.
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J Med Chem
; 61(3): 1130-1152, 2018 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29298069
6.
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.
ACS Chem Biol
; 12(12): 2970-2974, 2017 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29088528
7.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28498658
8.
Non-peptidic HIV protease inhibitors.
Curr Top Med Chem
; 4(10): 1097-114, 2004.
Artigo
Inglês
| MEDLINE | ID: mdl-15193141