Detalhe da pesquisa
1.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31307887
2.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38431835
3.
Nucleotide competing reverse transcriptase inhibitors: discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett
; 23(9): 2781-6, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23545107
4.
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett
; 23(13): 3967-75, 2013 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23673016
5.
Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2775-80, 2013 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23511023
6.
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Bioorg Med Chem Lett
; 21(3): 1041-6, 2011 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21215624
7.
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
J Med Chem
; 64(7): 3843-3869, 2021 04 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33749283
8.
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.
Bioorg Med Chem Lett
; 20(24): 7440-3, 2010 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21044840
9.
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.
Commun Biol
; 3(1): 719, 2020 11 27.
Artigo
Inglês
| MEDLINE | ID: mdl-33247181
10.
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
J Med Chem
; 50(4): 794-806, 2007 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-17300164
11.
Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus.
ACS Med Chem Lett
; 7(5): 525-30, 2016 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27190604
12.
Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.
J Med Chem
; 56(17): 7073-83, 2013 Sep 12.
Artigo
Inglês
| MEDLINE | ID: mdl-23919803
13.
Comparison of MALDI to ESI on a triple quadrupole platform for pharmacokinetic analyses.
Anal Chem
; 79(23): 9000-6, 2007 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17944440
14.
In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites.
Bioorg Med Chem Lett
; 17(2): 301-4, 2007 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17095220
15.
Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: impacts of glutathione trapping and glucuronide conjugation on covalent binding.
Bioorg Med Chem Lett
; 17(11): 3038-43, 2007 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17418572
16.
Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.
Proc Natl Acad Sci U S A
; 103(17): 6682-7, 2006 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-16617107
17.
Identification of an indole series of prostaglandin D2 receptor antagonists.
Bioorg Med Chem Lett
; 16(11): 3043-8, 2006 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16529930