Detalhe da pesquisa
1.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 179(2): 417-431.e19, 2019 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31585081
2.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 180(2): 406, 2020 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31978350
3.
Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions.
J Pharmacokinet Pharmacodyn
; 48(3): 321-338, 2021 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-33797011
4.
An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia.
Blood
; 129(5): 609-618, 2017 02 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27908880
5.
Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver.
J Pharmacol Exp Ther
; 367(1): 168-183, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30087156
6.
gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development.
J Pharmacokinet Pharmacodyn
; 45(2): 259-275, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29302838
7.
Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver.
J Pharmacokinet Pharmacodyn
; 45(4): 557-575, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29704219
8.
Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.
Pharm Res
; 32(6): 1884-93, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25446772
9.
Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats.
Anal Chem
; 86(16): 8149-57, 2014 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25072516
10.
Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and Pharmacodynamics of Efmarodocokin Alfa, a Variably Glycosylated Fusion Protein.
J Pharm Sci
; 2024 Mar 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38561054
11.
Exposing the molecular heterogeneity of glycosylated biotherapeutics.
Nat Commun
; 15(1): 3259, 2024 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38627419
12.
A mechanistic PK/PD model to enable dose selection of the potent anti-tryptase antibody (MTPS9579A) in patients with moderate-to-severe asthma.
Clin Transl Sci
; 16(4): 694-703, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36755366
13.
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFß3 Antibody for the Treatment of Fibrotic Diseases.
J Pharm Sci
; 112(11): 2910-2920, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37429356
14.
Pharmacokinetic/pharmacodynamic modeling of methylprednisolone effects on iNOS mRNA expression and nitric oxide during LPS-induced inflammation in rats.
Pharm Res
; 29(8): 2060-9, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22422321
15.
Integrated systems modeling of severe asthma: Exploration of IL-33/ST2 antagonism.
CPT Pharmacometrics Syst Pharmacol
; 11(9): 1268-1277, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35857704
16.
Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies.
Pharmaceutics
; 14(5)2022 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35631556
17.
Dose-dependent inactivation of airway tryptase with a novel dissociating anti-tryptase antibody (MTPS9579A) in healthy participants: A randomized trial.
Clin Transl Sci
; 15(2): 451-463, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34581002
18.
Mechanistic modeling of the effects of glucocorticoids and circadian rhythms on adipokine expression.
J Pharmacol Exp Ther
; 337(3): 734-46, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21398515
19.
TGFß2 and TGFß3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med
; 13(605)2021 08 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34349032
20.
Circadian signatures in rat liver: from gene expression to pathways.
BMC Bioinformatics
; 11: 540, 2010 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21040584