RESUMO
Experimental preclinical investigations on a group of 90 white outbred male rats showed that preliminary preventive introduction of procaine (novocaine, 1.07 mg/kg) or taurine (7.14 mg/kg) during 7 days before the administration of ketorolak trometamine significantly reduced the number of erosive-ulcerous lesions (by more than 87%, p < 0.001) and decreased the extent of pathological changes in the morphological structure of stomach mucus membrane.
Assuntos
Anestésicos Locais/farmacologia , Anti-Inflamatórios não Esteroides/efeitos adversos , Cetorolaco de Trometamina/efeitos adversos , Procaína/farmacologia , Úlcera Gástrica , Taurina/farmacologia , Animais , Anti-Inflamatórios não Esteroides/farmacologia , Cetorolaco de Trometamina/farmacologia , Masculino , Ratos , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/tratamento farmacológico , Úlcera Gástrica/patologiaRESUMO
Type A Cl. perfringens toxin caused necrosis in guniea-pigs and killed mice. Sodium nucleinate, administered orally to these animals simultaneously with the injection of the toxin and 2 hours later significantly prevented dermonecrosis in guinea-pigs and death in mice, as well as the development of pathomorphological changes in the liver, the kidneys and the spleen, the fatty degeneration of hepatocytes and disturbances in nucleic acid metabolism in these cells.