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1.
Int J Neural Syst ; : 2450053, 2024 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-39017038

RESUMO

Recently, Graph Neural Networks (GNNs) have gained widespread application in automatic brain network classification tasks, owing to their ability to directly capture crucial information in non-Euclidean structures. However, two primary challenges persist in this domain. First, within the realm of clinical neuro-medicine, signals from cerebral regions are inevitably contaminated with noise stemming from physiological or external factors. The construction of brain networks heavily relies on set thresholds and feature information within brain regions, making it susceptible to the incorporation of such noises into the brain topology. Additionally, the static nature of the artificially constructed brain network's adjacent structure restricts real-time changes in brain topology. Second, mainstream GNN-based approaches tend to focus solely on capturing information interactions of nearest neighbor nodes, overlooking high-order topology features. In response to these challenges, we propose an adaptive unsupervised Spatial-Temporal Dynamic Hypergraph Information Bottleneck (ST-DHIB) framework for dynamically optimizing brain networks. Specifically, adopting an information theory perspective, Graph Information Bottleneck (GIB) is employed for purifying graph structure, and dynamically updating the processed input brain signals. From a graph theory standpoint, we utilize the designed Hypergraph Neural Network (HGNN) and Bi-LSTM to capture higher-order spatial-temporal context associations among brain channels. Comprehensive patient-specific and cross-patient experiments have been conducted on two available datasets. The results demonstrate the advancement and generalization of the proposed framework.

2.
PLoS One ; 18(7): e0288658, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37440581

RESUMO

Manual image segmentation consumes time. An automatic and accurate method to segment multimodal brain tumors using context information rich three-dimensional medical images that can be used for clinical treatment decisions and surgical planning is required. However, it is a challenge to use deep learning to achieve accurate segmentation of medical images due to the diversity of tumors and the complex boundary interactions between sub-regions while limited computing resources hinder the construction of efficient neural networks. We propose a feature fusion module based on a hierarchical decoupling convolution network and an attention mechanism to improve the performance of network segmentation. We replaced the skip connections of U-shaped networks with a feature fusion module to solve the category imbalance problem, thus contributing to the segmentation of more complicated medical images. We introduced a global attention mechanism to further integrate the features learned by the encoder and explore the context information. The proposed method was evaluated for enhance tumor, whole tumor, and tumor core, achieving Dice similarity coefficient metrics of 0.775, 0.900, and 0.827, respectively, on the BraTS 2019 dataset and 0.800, 0.902, and 0.841, respectively on the BraTS 2018 dataset. The results show that our proposed method is inherently general and is a powerful tool for brain tumor image studies. Our code is available at: https://github.com/WSake/Feature-interaction-network-based-on-Hierarchical-Decoupled-Convolution.


Assuntos
Neoplasias Encefálicas , Humanos , Neoplasias Encefálicas/diagnóstico por imagem , Benchmarking , Redes Neurais de Computação , Processamento de Imagem Assistida por Computador
3.
IEEE Trans Image Process ; 31: 392-404, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34874855

RESUMO

RGBT tracking receives a surge of interest in the computer vision community, but this research field lacks a large-scale and high-diversity benchmark dataset, which is essential for both the training of deep RGBT trackers and the comprehensive evaluation of RGBT tracking methods. To this end, we present a La rge- s cale H igh-diversity [Formula: see text]nchmark for short-term R GBT tracking (LasHeR) in this work. LasHeR consists of 1224 visible and thermal infrared video pairs with more than 730K frame pairs in total. Each frame pair is spatially aligned and manually annotated with a bounding box, making the dataset well and densely annotated. LasHeR is highly diverse capturing from a broad range of object categories, camera viewpoints, scene complexities and environmental factors across seasons, weathers, day and night. We conduct a comprehensive performance evaluation of 12 RGBT tracking algorithms on the LasHeR dataset and present detailed analysis. In addition, we release the unaligned version of LasHeR to attract the research interest for alignment-free RGBT tracking, which is a more practical task in real-world applications. The datasets and evaluation protocols are available at: https://github.com/mmic-lcl/Datasets-and-benchmark-code.

4.
Front Pharmacol ; 13: 978151, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36188624

RESUMO

Non-coding RNA is still one of the most popular fields in biology research. In recent years, people paid more attention to the roles of H19 in lung diseases, which expressed abnormally in various pathological process. Therefore, this review focus on the regulatory role of H19 in asthma, pulmonary arterial hypertension (PAH), idiopathic pulmonary fibrosis (IPF), lung injury, pneumonia, lung cancer, etc. And the potential therapeutic agents and molecular treatments of H19 are collected. The aim is to demonstrate its underlying mechanism in pulmonary diseases and to guide the basic research targeting H19 into clinical drug translation.

5.
Sci Rep ; 6: 24115, 2016 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-27066904

RESUMO

Community detection in complex network has become a vital step to understand the structure and dynamics of networks in various fields. However, traditional node clustering and relatively new proposed link clustering methods have inherent drawbacks to discover overlapping communities. Node clustering is inadequate to capture the pervasive overlaps, while link clustering is often criticized due to the high computational cost and ambiguous definition of communities. So, overlapping community detection is still a formidable challenge. In this work, we propose a new overlapping community detection algorithm based on network decomposition, called NDOCD. Specifically, NDOCD iteratively splits the network by removing all links in derived link communities, which are identified by utilizing node clustering technique. The network decomposition contributes to reducing the computation time and noise link elimination conduces to improving the quality of obtained communities. Besides, we employ node clustering technique rather than link similarity measure to discover link communities, thus NDOCD avoids an ambiguous definition of community and becomes less time-consuming. We test our approach on both synthetic and real-world networks. Results demonstrate the superior performance of our approach both in computation time and accuracy compared to state-of-the-art algorithms.

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