Analytical Solution for Dynamic Response of a Reinforced Concrete Beam with Viscoelastic Bearings Subjected to Moving Loads.

To provide a theoretical basis for eliminating resonance and optimizing the design of viscoelastically supported bridges, this paper investigates the analytical solutions of train-induced vibrations in railway bridges with low-stiffness and high-damping rubber bearings. First, the shape function of the viscoelastic bearing reinforced concrete (RC) beam is derived for the dynamic response of the viscoelastic bearing RC beam subjected to a single moving load. Furthermore, based on the simplified shape function, the dynamic response of the viscoelastic bearing RC beam under equidistant moving loads is studied. The results show that the stiffness and damping effect on the dynamic response of the supports cannot be neglected. The support stiffness might adversely increase the dynamic response. Further, due to the effect of support damping, the free vibration response of RC beams in resonance may be significantly suppressed. Finally, when the moving loads leave the bridge, the displacement amplitude of the viscoelastic support beam in free vibration is significantly larger than that of the rigid support beam.

Synergistic neuroprotective effects of Geniposide and ursodeoxycholic acid in hypoxia-reoxygenation injury in SH-SY5Y cells.

Endoplasmic reticulum stress (ERS) and autophagy activation play important roles in the process of cerebral ischemia/reperfusion (I/R) injury. The synergistic protective effects of Geniposide and ursodeoxycholic acid against cellular apoptosis caused by oxygen-glucose deprivation-reoxygenation (OGD/R) were investigated using a Cell Counting Kit-8 assay, lactate dehydrogenase (LDH) assay, flow cytometry, quantitative polymerase chain reaction (qPCR), and western blotting to examine cellular viability, apoptosis, reactive oxygen species (ROS) levels, mRNA and protein levels, respectively, in relation to ERS and autophagy. We found that pretreatment with Geniposide improved cellular viability. Moreover, treatment with a combination of Geniposide and Tauroursodeoxycholic acid (TUDCA) (GT) protected injured cells better than Geniposide alone. Further studies showed that the increase in cellular ROS levels, and the overexpression of mRNA and proteins related to OGD/R-induced ERS and autophagy, were both counteracted by GT. Our study indicates that the protective effects of GT on OGD/R-induced apoptosis in SH-SY5Y cells are associated with the inhibition of ERS and autophagy.