Detalhe da pesquisa
1.
Investigation into MAO B-Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of (S)-Enantiomer of Indaneamine (RP101075) by MAO B.
Drug Metab Dispos
; 49(8): 601-609, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34011531
2.
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator.
Drug Metab Dispos
; 49(5): 405-419, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33674268
3.
Evaluation of iberdomide and cytochrome p450 drug-drug interaction potential in vitro and in a phase 1 study in healthy subjects.
Eur J Clin Pharmacol
; 77(2): 223-231, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-32965548
4.
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase.
Xenobiotica
; 51(12): 1416-1426, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-35000550
5.
Absorption, distribution, metabolism, and excretion of mTOR kinase inhibitor CC-223 in rats, dogs, and humans.
Xenobiotica
; 49(1): 43-53, 2019 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-29206565
6.
In vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903.
Xenobiotica
; 49(10): 1229-1236, 2019 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-30394160
7.
Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase.
Xenobiotica
; 49(1): 54-70, 2019 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-29297772
8.
Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans.
Xenobiotica
; 49(2): 200-210, 2019 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-29320949
9.
Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group.
Drug Metab Dispos
; 43(4): 620-30, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25655830
10.
Metabolism and disposition of a potent and selective JNK inhibitor [14C]tanzisertib following oral administration to rats, dogs and humans.
Xenobiotica
; 45(5): 428-41, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25482583
11.
In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism.
Xenobiotica
; 45(6): 465-80, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25475995
12.
Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary.
Xenobiotica
; 43(2): 219-25; discussion 226-7, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22803803
13.
Comparison of Pre-existing Anti-AAV8 Total Antibody Screening and Confirmatory Assays with a Cell-Based Neutralizing Assay in Normal Human Serum.
AAPS J
; 25(3): 35, 2023 04 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37012501
14.
Bioanalytical Methods for Characterization of CAR-T Cellular Kinetics: Comparison of PCR Assays and Matrices.
Clin Pharmacol Ther
; 114(3): 664-672, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37422675
15.
2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 15(16): 955-1016, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37650500
16.
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model. I. Amrubicin accumulates to a lower level than doxorubicin or epirubicin.
J Pharmacol Exp Ther
; 341(2): 464-73, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22338033
17.
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model. II. Amrubicin shows metabolic advantages over doxorubicin and epirubicin.
J Pharmacol Exp Ther
; 341(2): 474-83, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22338034
18.
Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults.
Cancer Chemother Pharmacol
; 90(4): 325-334, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36001108
19.
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 14(9): 505-580, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35578993
20.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg Med Chem Lett
; 21(8): 2394-9, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21414779