Detalhe da pesquisa
1.
Synthesis, characterization, and monkey PET studies of [¹8F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435.
Synapse
; 65(2): 125-35, 2011 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-20524178
2.
Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
Bioorg Med Chem Lett
; 20(2): 726-9, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20005101
3.
Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.
SLAS Discov
; 25(3): 287-298, 2020 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-31516076
4.
Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one.
J Pharmacol Exp Ther
; 330(1): 179-90, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19359526
5.
Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders.
Bioorg Med Chem Lett
; 19(18): 5310-3, 2009 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19692242
6.
Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist.
Bioorg Med Chem Lett
; 19(18): 5464-8, 2009 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19674894
7.
Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide].
J Pharmacol Exp Ther
; 326(2): 577-86, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-18487514
8.
Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist.
Bioorg Med Chem
; 16(22): 9817-29, 2008 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18849168
9.
Genomic organization of the gene that encodes the precursor to EGF-related peptides, exogastrula-inducing peptides, of the sea urchin Anthocidaris crassispina.
Biochim Biophys Acta
; 1574(3): 311-20, 2002 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-11997097
10.
Characterization of the upstream region that regulates the transcription of the gene for the precursor to EGF-related peptides, exogastrula-inducing peptides, of the sea urchin Anthocidaris crassispina.
Comp Biochem Physiol B Biochem Mol Biol
; 136(1): 15-26, 2003 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-12941636
11.
Development of a beta-lactamase reporter gene assay for metabotropic glutamate receptor 1 by using coexpression of glutamate transporter.
J Biomol Screen
; 15(2): 148-58, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-20086213
12.
Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents.
Eur J Pharmacol
; 639(1-3): 106-14, 2010 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-20371227
13.
Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one.
Neuropharmacology
; 57(4): 438-45, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19559036
14.
Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists.
J Pharmacol Sci
; 110(3): 315-25, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19542684
15.
In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
J Pharmacol Exp Ther
; 323(1): 147-56, 2007 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-17609420
16.
Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC).
J Pharmacol Exp Ther
; 321(3): 1144-53, 2007 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-17360958