Detalhe da pesquisa
1.
Impact of GPCR Structures on Drug Discovery.
Cell
; 181(1): 81-91, 2020 04 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32243800
2.
Delineating the Ligand-Receptor Interactions That Lead to Biased Signaling at the µ-Opioid Receptor.
J Chem Inf Model
; 61(7): 3696-3707, 2021 07 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34251810
3.
The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Nav 1.7 channel blocker.
Biopharm Drug Dispos
; 39(8): 388-393, 2018 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-30175851
4.
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.
Bioorg Med Chem Lett
; 27(21): 4805-4811, 2017 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29029933
5.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Proc Natl Acad Sci U S A
; 110(29): E2724-32, 2013 Jul 16.
Artigo
Inglês
| MEDLINE | ID: mdl-23818614
6.
Recent progress in sodium channel modulators for pain.
Bioorg Med Chem Lett
; 24(16): 3690-9, 2014 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25060923
7.
Synthesis of novel histamine H4 receptor antagonists.
Bioorg Med Chem Lett
; 22(2): 1156-9, 2012 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22189138
8.
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Bioorg Med Chem Lett
; 21(21): 6596-602, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21920751
9.
Discovery of a Series of Indazole TRPA1 Antagonists.
ACS Med Chem Lett
; 8(6): 666-671, 2017 Jun 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28626530
10.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
J Med Chem
; 60(16): 7029-7042, 2017 08 24.
Artigo
Inglês
| MEDLINE | ID: mdl-28682065
11.
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
PLoS One
; 11(4): e0152405, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27050761
12.
Voltage gated sodium channels as drug discovery targets.
Channels (Austin)
; 9(6): 360-6, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26646477
13.
An efficient synthesis of endo,exo-furofuranone derivatives.
Chem Commun (Camb)
; (18): 2042-3, 2002 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-12357770
14.
Intramolecular C-H insertions adjacent to sulfur for the diastereoselective synthesis of thienofuranones.
Chem Commun (Camb)
; (15): 1772-3, 2004 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-15278179
15.
Ion channels as therapeutic targets: a drug discovery perspective.
J Med Chem
; 56(3): 593-624, 2013 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23121096
16.
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
J Med Chem
; 52(4): 1219-23, 2009 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-19175319
17.
A versatile stereoselective synthesis of endo,exo-furofuranones: application to the enantioselective synthesis of furofuran lignans.
J Org Chem
; 69(1): 122-9, 2004 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-14703387