Detalhe da pesquisa
1.
High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II.
Int J Mol Sci
; 21(15)2020 Jul 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32751752
2.
Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.
Bioorg Med Chem Lett
; 29(4): 674-680, 2019 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30522953
3.
Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency.
Bioorg Med Chem
; 26(4): 957-969, 2018 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28919180
4.
Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.
Bioorg Med Chem Lett
; 25(2): 367-71, 2015 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25466710
5.
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Bioorg Med Chem Lett
; 23(17): 4953-9, 2013 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23867164
6.
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Elife
; 122023 Oct 24.
Artigo
Inglês
| MEDLINE | ID: mdl-37874617
7.
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Bioorg Med Chem Lett
; 22(13): 4296-302, 2012 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22672799
8.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36469401
9.
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Sci Transl Med
; 14(648): eabj2658, 2022 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35675433
10.
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32461332
11.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32461331
12.
Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: the development pipeline and recent clinical data.
Curr Opin Drug Discov Devel
; 11(4): 458-70, 2008 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18600563
13.
Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.
Bioorg Med Chem Lett
; 18(15): 4348-51, 2008 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18625554
14.
Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 18(15): 4352-4, 2008 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18632268
15.
Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.
J Med Chem
; 61(20): 9360-9370, 2018 10 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30226381
16.
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
J Clin Invest
; 128(5): 2144-2155, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29600961
17.
Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.
J Med Chem
; 58(17): 6733-46, 2015 Sep 10.
Artigo
Inglês
| MEDLINE | ID: mdl-25915084
18.
Promiscuity and the conformational rearrangement of drug-like molecules: insight from the protein data bank.
ChemMedChem
; 10(2): 238-44, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25491400
19.
Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.
J Med Chem
; 58(1): 512-6, 2015 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24712864
20.
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.
Sci Transl Med
; 7(273): 273ra15, 2015 Feb 04.
Artigo
Inglês
| MEDLINE | ID: mdl-25653221