Detalhe da pesquisa
1.
Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals With Elevated Plasma Lipoprotein(a) Levels.
JAMA
; 327(17): 1679-1687, 2022 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35368052
2.
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
BMC Cardiovasc Disord
; 19(1): 240, 2019 10 29.
Artigo
Inglês
| MEDLINE | ID: mdl-31664920
3.
Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.
Am J Hum Genet
; 94(2): 198-208, 2014 Feb 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24462370
4.
Genetic insights into statin-associated diabetes risk.
Curr Opin Lipidol
; 27(2): 125-30, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26959703
5.
Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.
Hum Genet
; 135(5): 453-467, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26946290
6.
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Lancet
; 385(9965): 351-61, 2015 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-25262344
7.
Mendelian Randomization and Type 2 Diabetes.
Cardiovasc Drugs Ther
; 30(1): 51-7, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26809778
8.
Mendelian randomization of blood lipids for coronary heart disease.
Eur Heart J
; 36(9): 539-50, 2015 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24474739
9.
Genetic risk factors and Mendelian randomization in cardiovascular disease.
Curr Cardiol Rep
; 17(5): 33, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25894797
10.
A dysglycaemic effect of statins in diabetes: relevance to clinical practice?
Diabetologia
; 57(12): 2433-5, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25335441
11.
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.
Eur Heart J
; 34(13): 972-81, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22977227
12.
Interleukin-6 receptor pathways in abdominal aortic aneurysm.
Eur Heart J
; 34(48): 3707-16, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23111417
13.
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Lancet
; 379(9822): 1214-24, 2012 Mar 31.
Artigo
Inglês
| MEDLINE | ID: mdl-22421340
14.
The genetics of coronary heart disease.
Br Med Bull
; 102: 59-77, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22577178
15.
Pharmacotherapy for children with elevated levels of lipoprotein(a): future directions.
Expert Opin Pharmacother
; 23(14): 1601-1615, 2022 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-36047306
16.
Treatment and prevention of lipoprotein(a)-mediated cardiovascular disease: the emerging potential of RNA interference therapeutics.
Cardiovasc Res
; 118(5): 1218-1231, 2022 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33769464
17.
Pre-clinical assessment of SLN360, a novel siRNA targeting LPA, developed to address elevated lipoprotein (a) in cardiovascular disease.
Atherosclerosis
; 349: 240-247, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35400495
18.
Mendelian randomisation study for statin treatment - Authors' reply.
Lancet
; 385(9981): 1946, 2015 May 16.
Artigo
Inglês
| MEDLINE | ID: mdl-26090640
19.
Mendelian randomization for studying the effects of perturbing drug targets.
Wellcome Open Res
; 6: 16, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33644404
20.
The genomics of heart failure: design and rationale of the HERMES consortium.
ESC Heart Fail
; 8(6): 5531-5541, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34480422