Post-coital contraception with dienoestrol.

PIP: A clinical investigation using dienestrol on 30 fertile women ingesting it postcoitally in May 1967 was undertaken to determine the agent's effectiveness as a postcoital oral contraceptive (OC). The first group of 10 taking 10 mg following each intercourse yielded few side effects, only 1 case of permanent nausea and 1 of sporadic nausea, no pregnancies from a total of 50 cycles and regularity of menstrual cycles dependent upon frequency of intercourse. In the second group of 20 taking 2.5 mg dienestrol and .2 mg ethynodiol-diacetate for a total of 60 cycles, no pregnancies occurred despite repeated midcycle coitus, moderate nausea in all 3 cycles of 2 women and sporadically in 2 other women, breast discomfort in 6% of cycles and mostly regular cycles and "silent menstruation" in 5 patients as a result of more frequent pill use were noted. Relatively low doses can effectively prevent pregnancy with few side effects. Cycle disturbances occurring only if tablets are taken without interruption, can be prevented by taking 3 tablets of a combination of dienestrol with a low dose of highly potent progestogen following intercourse. More study is needed, but this OC might be the method of choice for some.^ieng

[Investigations of amniotic fluid after intraamnial application of prostaglandin F 2 alpha (author's transl)]. / Fruchtwasseruntersuchungen nach intraamnialer Applikation von Prostaglandin F 2 alpha

PIP: In 11 cases of abortion induced by (PGF2alpha) prostaglandin F2alpha, the authors studied the cinetic behavior of PGF2alpha in amniotic fluid using gas chromatography. In early pregnancy, the biologic 1/2-life is shorter than in later pregnancy. They assume that considerable paraplacentar diffusion is the reason for this. Cinetic investigations suggest that the vital functions of the fetus remain unchanged until it is expelled. There was no time correlation between the 1/2-life time and time of induction of abortion. (author's)^ieng

Interruption of pregnancy by PGF 2 alpha. II. Extraovular administration.

PIP: The prostaglandin PGF2alpha was administered extraovularly to 38 health women aged 17-37 to induce abortion. The women were in the first trimester of pregnancy. The prostaglandin was given every 2nd hour in doses of 250-1000 mcg, depending on the frequency and intensity of the uterine contractions and on the side effects. Abortion took place within 36 hours (mean, 21.6 hours) in 26 (68.4%) of the cases. The quantity of PGF2alpha administered was 2.25-14.75 mg, with an average of 6.72 mg. Side effects (most notably, vomiting and diarrhea) occurred in 27 cases, but they did not interrupt the intermittent PG treatment. No essential changes in the results of laboratory tests were noted.^ieng

Human fetal and adult spleen phospholipids and their fatty acid composition.

Total phospholipid contents and the individual phospholipid components of human adult and fetal spleens from 17--18 and 23--24 week's pregnancies composition of sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, diphosphatidylglycerol and phosphatidic acid studied in human adult, 17--18 and 23--24 week fetal spleens.