Detalhe da pesquisa
1.
Structural analysis of human KDM5B guides histone demethylase inhibitor development.
Nat Chem Biol
; 12(7): 539-45, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27214403
2.
Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor.
EMBO J
; 31(6): 1605-16, 2012 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22314234
3.
A scintillation proximity assay for histone demethylases.
Anal Biochem
; 463: 54-60, 2014 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25010373
4.
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate.
J Med Chem
; 67(6): 4525-4540, 2024 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38294854
5.
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.
Structure
; 29(11): 1241-1252.e5, 2021 11 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34233201
6.
Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.
J Mol Biol
; 429(19): 2895-2906, 2017 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28827149
7.
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell Chem Biol
; 24(3): 371-380, 2017 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28262558
8.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26741168
9.
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Medchemcomm
; 5(12): 1879-1886, 2014 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26682034