Detalhe da pesquisa
1.
The epichaperome is an integrated chaperome network that facilitates tumour survival.
Nature
; 538(7625): 397-401, 2016 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27706135
2.
NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J Biol Chem
; 294(44): 16010-16019, 2019 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31501246
3.
Structures of Hsp90α and Hsp90ß bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins
; 87(10): 869-877, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31141217
4.
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Blood
; 127(7): 858-68, 2016 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26603836
5.
Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.
Tetrahedron Lett
; 58(48): 4525-4531, 2017 Nov 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30026636
6.
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.
Blood
; 123(13): 2075-83, 2014 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24470592
7.
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
J Labelled Comp Radiopharm
; 59(3): 129-32, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26806023
8.
Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.
Blood
; 122(16): 2837-47, 2013 Oct 17.
Artigo
Inglês
| MEDLINE | ID: mdl-23943653
9.
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Nat Chem Biol
; 9(11): 677-84, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23995768
10.
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.
Biochim Biophys Acta
; 1823(3): 742-55, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22062686
11.
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Nat Chem Biol
; 7(11): 818-26, 2011 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-21946277
12.
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.
Beilstein J Org Chem
; 9: 544-556, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23616796
13.
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.
Nat Commun
; 14(1): 3742, 2023 06 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37353488
14.
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Proc Natl Acad Sci U S A
; 106(20): 8368-73, 2009 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-19416831
15.
Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.
Bioorg Med Chem Lett
; 21(18): 5347-52, 2011 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21802945
16.
Design, synthesis, and evaluation of small molecule Hsp90 probes.
Bioorg Med Chem
; 19(8): 2603-14, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21459002
17.
Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas.
Cancer Res
; 81(20): 5202-5216, 2021 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34479963
18.
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.
Nat Commun
; 12(1): 4669, 2021 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34344873
19.
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
Commun Biol
; 4(1): 1333, 2021 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-34824367
20.
Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
J Org Chem
; 75(9): 2820-35, 2010 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-20392070