Detalhe da pesquisa
1.
Engineering CAR-T cells to activate small-molecule drugs in situ.
Nat Chem Biol
; 18(2): 216-225, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34969970
2.
Design and synthesis of a library of C2-substituted sulfamidoadenosines to probe bacterial permeability.
Bioorg Med Chem Lett
; 97: 129486, 2024 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37734424
3.
Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics.
Antimicrob Agents Chemother
; 67(2): e0137722, 2023 02 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36715507
4.
Cheminformatic analysis of natural product-based drugs and chemical probes.
Nat Prod Rep
; 39(1): 20-32, 2022 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34342327
5.
Defining new chemical space for drug penetration into Gram-negative bacteria.
Nat Chem Biol
; 16(12): 1293-1302, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33199906
6.
Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
Proc Natl Acad Sci U S A
; 116(31): 15475-15484, 2019 07 30.
Artigo
Inglês
| MEDLINE | ID: mdl-31235585
7.
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.
Biochemistry
; 58(14): 1918-1930, 2019 04 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30912442
8.
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents.
Biochemistry
; 58(6): 833-847, 2019 02 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30582694
9.
Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction.
Chemistry
; 24(50): 13150-13157, 2018 Sep 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29936701
10.
Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction.
Tetrahedron
; 74(26): 3370-3383, 2018 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-30467444
11.
Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis.
Acc Chem Res
; 49(9): 1741-56, 2016 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27568877
12.
Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding.
J Org Chem
; 82(1): 57-75, 2017 01 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28004933
13.
Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery.
Isr J Chem
; 57(3-4): 279-291, 2017 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-29104308
14.
Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.
Bioorg Med Chem Lett
; 26(21): 5340-5345, 2016 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27692545
15.
Active site remodelling accompanies thioester bond formation in the SUMO E1.
Nature
; 463(7283): 906-12, 2010 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-20164921
16.
Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.
Biochemistry
; 54(42): 6514-6524, 2015 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-26394156
17.
Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
Nat Chem Biol
; 9(1): 21-9, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23160003
18.
Cheminformatic comparison of approved drugs from natural product versus synthetic origins.
Bioorg Med Chem Lett
; 25(21): 4802-4807, 2015 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26254944
19.
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
Nat Chem Biol
; 8(4): 358-65, 2012 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-22406518
20.
Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol.
Bioorg Med Chem
; 22(21): 5917-23, 2014 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25284254