Unilateral congenital malformations of middle ear with intact external ear: a review of 64 cases.

OBJECTIVE: To describe the operative findings and surgical results of unilateral congenital middle ear malformations with intact external ear. METHODS: A retrospective review was performed on 64 patients with unilateral congenital middle ear malformations and intact external ear who underwent exploratory tympanotomy from 2011 to 2016. Demographic data, clinical data, high-resolution computed tomography findings, audiometric data and intraoperative findings were collected. Audiological evaluations before and 6 months after surgery were analyzed in 47 patients. RESULTS: The most common malformation were mobile stapes with missing incus long process and stapes suprastructure. The air conduction pure tone average was 58.9 ± 10.5 dB HL (range 34.4-78.1 dB HL) preoperatively and 28.8 ± 10.6 dB HL (range 9.4-55.6 dB HL) postoperatively (P = 0.000). Twenty-five cases (53.2%) acquired an air conduction hearing gain exceeding 30 dB. Mean air-bone gap (ABG) was 44.5 ± 9.4 dB (range 22.5-66.4 dB HL) before surgery and 15.6 ± 9.3 dB (range 0-35.6 dB) after surgery (P = 0.000) for an average gain of 28.8 ± 11.5 dB. Thirty-four cases (72.3%) showed a postoperative ABG of less than 20 dB, 15 had an ABG within 10 dB, and 4 had 0 dB ABG after operation. No significant difference was observed for air conduction hearing gain regarding age (P = 0.261) or types of malformations (mobile stapes footplate with or without a suprastructure anomaly, P = 0.058). CONCLUSION: Unilateral congenital middle ear malformations with intact external ear can be complex and diverse. Functional ossiculoplasty for patients with unilateral congenital middle ear malformations can achieve good hearing outcomes.

Adaptive reconstruction for coded aperture temporal compressive imaging.

This paper presents an adaptive reconstruction method for coded aperture temporal compressive imaging. A pixel-wise equal-exposure coding strategy is first implemented to induce speckle-like features in the moving area of the measured image. A moving area detection method is then proposed to reconstruct the adaptively segmented moving areas into a series of video frames, which are filled back into the stationary clear background. Both simulation and experimental results demonstrate that the proposed method significantly reduces the time consumption of video reconstruction without degradation of image quality.

Brain structure links everyday creativity to creative achievement.

Although creativity is commonly considered to be a cornerstone of human progress and vital to all realms of our lives, its neural basis remains elusive, partly due to the different tasks and measurement methods applied in research. In particular, the neural correlates of everyday creativity that can be experienced by everyone, to some extent, are still unexplored. The present study was designed to investigate the brain structure underlying individual differences in everyday creativity, as measured by the Creative Behavioral Inventory (CBI) (N=163). The results revealed that more creative activities were significantly and positively associated with larger gray matter volume (GMV) in the regional premotor cortex (PMC), which is a motor planning area involved in the creation and selection of novel actions and inhibition. In addition, the gray volume of the PMC had a significant positive relationship with creative achievement and Art scores, which supports the notion that training and practice may induce changes in brain structures. These results indicate that everyday creativity is linked to the PMC and that PMC volume can predict creative achievement, supporting the view that motor planning may play a crucial role in creative behavior.

An illustrated heuristic prototype facilitates scientific inventive problem solving: A functional magnetic resonance imaging study.

Many scientific inventions (SI) throughout history were inspired by heuristic prototypes (HPs). For instance, an event or piece of knowledge similar to displaced water from a tub inspired Archimedes' principle. However, the neural mechanisms underlying this insightful problem solving are not very clear. Thus, the present study explored the neural correlates used to solve SI problems facilitated by HPs. Each HP had two versions: a literal description with an illustration (LDI) and a literal description with no illustration (LDNI). Thirty-two participants were divided randomly into these two groups. Blood oxygenation level-dependent fMRI contrasts between LDI and LDNI groups were measured. Greater activity in the right middle occipital gyrus (RMOG, BA19), right precentral gyrus (RPCG, BA4), and left middle frontal gyrus (LMFG, BA46) were found within the LDI group as compared to the LDNI group. We discuss these results in terms cognitive functions within these regions related to problem solving and memory retrieval.

Activation of Src Kinase Mediates the Disruption of Adherens Junction in the Blood-labyrinth Barrier after Acoustic Trauma.

BACKGROUND: Adherens junction in the blood-labyrinth barrier is largely unexplored because it is traditionally thought to be less important than the tight junction. Since increasing evidence indicates that it actually functions upstream of tight junction adherens junction may potentially be a better target for ameliorating the leakage of the blood-labyrinth barrier under pathological conditions such as acoustic trauma. AIMS: This study was conducted to investigate the pathogenesis of the disruption of adherens junction after acoustic trauma and explore potential therapeutic targets. METHODS: Critical targets that regulated the disruption of adherens junction were investigated by techniques such as immunofluorescence and Western blottingin C57BL/6J mice. RESULTS: Upregulation of Vascular Endothelial Growth Factor (VEGF) and downregulation of Pigment Epithelium-derived Factor (PEDF) coactivated VEGF-PEDF/VEGF receptor 2 (VEGFR2) signaling pathway in the stria vascularis after noise exposure. Downstream effector Src kinase was then activated to degrade VE-cadherin and dissociate adherens junction which led to the leakage of the blood-labyrinth barrier. By inhibiting VEGFR2 or Src kinase VE-cadherin degradation and blood-labyrinth barrier leakage could be attenuated but Src kinase represented a better target to ameliorate blood-labyrinth barrier leakage as inhibiting it would not interfere with vascular endothelium repair neurotrophy and pericytes proliferation mediated by upstream VEGFR2. CONCLUSION: Src kinase may represent a promising target to relieve noise-induced disruption of adherens junction and hyperpermeability of the blood-labyrinth barrier.

Students' Online Information Searching Strategies and Their Creative Question Generation: The Moderating Effect of Their Need for Cognitive Closure.

With the wide application of computers and digital technologies, online information searching is being integrated into students' learning process. Improving students' creative question generation through online information searching is an emerging research topic in the creativity and pedagogy field. Online information searching brings diversified information, but it also leads to cognitive load brought by a large amount of online information. Using online information searching to generate creative questions depends on students' cognitive properties. However, the existing literature ignores the joint influence of students' online information searching strategies and cognitive properties on their creative question generation. This study puts forward three hypotheses: first, the two strategies of students' online information searching ("keywords" and "Web page exploration") will increase their creative question generation; second, the impact of "keywords" is negatively moderated by students' need for cognitive closure (NFCC); third, the impact of "Web page exploration" is positively moderated by NFCC. The main reason is that high NFCC prevents students from obtaining diversified perspectives by using different keywords, but it helps to avoid distractions caused by a large amount of online information and promote the persistency of their reading information. Based on the data of quasi-experimental tasks completed by 90 students in Grade 7 and Grade 8, the results support the above hypothesis. The contributions of creative question generation theory and NFCC theory, as well as important issues of future study, are discussed.

Vein pattern recognition based on RGB images using Monte Carlo simulation and ridge tracking.

In forensic investigations, images of evidence can often be obtained from crimes such as child pornography and masked violent riots. However, identifying criminals is usually very difficult and sometimes impossible because these images usually contain skin of body parts, while their faces and other commonly used biometrics are unavailable. Vein patterns are a potential biometric to solve this problem. Traditional systems use near-infrared (NIR) imaging technologies to obtain vein patterns, which cannot be applied to forensic analysis since only RGB images are available. However, veins are unobservable in RGB images. In this paper, a comprehensive scheme including a vein uncovering algorithm, a vein extraction algorithm, and a vein pattern matching algorithm is presented. Based on the Monte Carlo (MC) simulation of light transmission in a skin optical model, physical parameters corresponding to different skin colors are obtained, and vein patterns are uncovered from the parameter distribution images. After preprocessing with cubic convolution and Gabor filtering, vein lines are extracted based on ridge tracking. Local gradient orientation and the geometric direction of veins are utilized to guarantee the correct tracking direction. Hessian-based Frangi filters are adopted to locate potential veins. In the matching step, effective minutiae are extracted to represent the topology of vein patterns. A modified coherent point drift (CPD) algorithm is proposed utilizing coordinates, Gabor energy values, and curvatures of minutiae to match vein patterns. Comprehensive experiments were carried out to evaluate the proposed three algorithms. Experimental results show the superiority of the proposed algorithms to various state-of-the-art methods.

Visualizing veins from color images under varying illuminations for medical applications.

SIGNIFICANCE: Effective vein visualization is critically important for several clinical procedures, such as venous blood sampling and intravenous injection. Existing technologies using infrared device or ultrasound rely on professional equipment and are not suitable for daily medical care. A regression-based vein visualization method is proposed. AIM: We visualize veins from conventional RGB images to provide assistance in venipuncture procedures as well as clinical diagnosis of some venous insufficiency. APPROACH: The RGB images taken by digital cameras are first transformed to spectral reflectance images using Wiener estimation. Multiple regression analysis is then applied to derive the relationship between spectral reflectance and the concentrations of pigments. Monte Carlo simulation is adopted to get prior information. Finally, vein patterns are visualized from the spatial distribution of pigments. To minimize the effect of illumination on skin color, light correction and shading removal operations are performed in advance. RESULTS: Experimental results from inner forearms of 60 subjects show the effectiveness of the regression-based method. Subjective and objective evaluations demonstrate that the clarity and completeness of vein patterns can be improved by light correction and shading removal. CONCLUSIONS: Vein patterns can be successfully visualized from RGB images without any professional equipment. The proposed method can assist in venipuncture procedures. It also shows promising potential to be used in clinical diagnosis and treatment of some venous insufficiency.

How Family's Support of Perseverance in Creative Efforts Influences the Originality of Children's Drawing During the Period of COVID-19 Pandemic?

This study points out that families' support of perseverance in creative efforts will increase children's originality of creative drawing through children's persistence in information searching. Data analysis based on 134 Chinese young children's creative drawings and survey supports the above hypothesis. Moreover, children's exposure to COVID-19 pandemic positively moderates the relationship between supporting perseverance and children's search persistence, such that high exposure to COVID-19 pandemic will increase the positive relationship between support of perseverance and search persistence. And children's prosocial motivation inhibits the influence of search persistence on originality. Contributions to the theory of children's creativity are discussed.

Perceived Work Uncertainty and Creativity During the COVID-19 Pandemic: The Roles of Zhongyong and Creative Self-Efficacy.

Research on the relationship between work stress and employee creativity has been mixed. This study on 823 female attorneys in China identifies employee creative self-efficacy and employees' value of Zhongyong as moderators in this relationship. In this study, work stress is assessed by the perceived work uncertainty brought on by the COVID-19 pandemic. Our study found that although Zhongyong, which involves an employee's ambidextrous thinking, can be helpful for employee creativity, low levels of Zhongyong are better for employee creativity in an uncertain context such as the COVID-19 pandemic, due to the fact that high levels of Zhongyong result in an overemphasis on compromise and giving in when times are uncertain. Instead, low levels of Zhongyong will decrease employees' concern about others' acceptance in an uncertain environment. In addition, creative self-efficacy motivates employees to engage in creative efforts during times of work uncertainty. In sum, this study found that employee perceived work uncertainty brought on by COVID-19 enhances employee creativity when an employee's value of Zhongyong is low and creative self-efficacy is high.

Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2/E1 in breast cancer tissues.

BACKGROUND: This study was conducted to investigate the exchange protein directly activated by cAMP (Epac1), PDE4, and PKC expression in breast cancer tissues, and the correlation between these proteins and AKAP95, Cx43, cyclin D2, and cyclin E1. METHODS: PV-9000 two-step immunohistochemistry was used to analyze protein expression. RESULTS: The positive rate of Epac1 protein expression in breast cancer tissues (58%) was higher than in para-carcinoma tissues (10%) (P < 0.05). There were no significant differences in the positive rates of PDE4 and PKC expression between breast cancer and para-carcinoma tissues (P > 0.05). The positive expression rate of PDE4 was higher in the P53 protein positive group compared to the P53 negative group (P < 0.05). Correlations between Epac1 and cyclin D2, PDE4 and cyclin D2, AKAP95 and PKC, Cx43 and PKC, and cyclin D2 and PKC proteins were observed (P < 0.05). CONCLUSION: Epac1 expression in breast cancer tissues was increased, suggesting that the protein may be involved in the development of breast cancer. Correlations between Epac1 and cyclin D2, PDE4 and cyclin D2, AKAP95 and PKC, Cx43 and PKC, and cyclin D2 and PKC proteins suggested synergistic effects among these proteins in the development of breast cancer.

A No-Reference Adaptive Blockiness Measure for JPEG Compressed Images.

Digital images have been extensively used in education, research, and entertainment. Many of these images, taken by consumer cameras, are compressed by the JPEG algorithm for effective storage and transmission. Blocking artifact is a well-known problem caused by this algorithm. Effective measurement of blocking artifacts plays an important role in the design, optimization, and evaluation of image compression algorithms. In this paper, we propose a no-reference objective blockiness measure, which is adaptive to high frequency component in an image. Difference of entropies across blocks and variation of block boundary pixel values in edge images are adopted to calculate the blockiness level in areas with low and high frequency component, respectively. Extensive experimental results prove that the proposed measure is effective and stable across a wide variety of images. It is robust to image noise and can be used for real-world image quality monitoring and control. Index Terms-JPEG, no-reference, blockiness measure.

[Analyses of the clinical characteristics of unilateral conductive hearing loss with intact tympanic membrane].

OBJECTIVE: To analyze the clinical characteristics of unilateral conductive hearing loss with intact tympanic membrane, and summarize the key diagnostic points, differential diagnosis and observe the effects of surgical treatment. METHODS: We reviewed data from 82 patients with unilateral conductive hearing loss with intact tympanic membranes who accepted the exploratory tympanotomy from April 2011 to September 2013. There were 41 males and 41 females, aged from 7 to 66( averaged 26.5±13.7)years, with a history of one month to 50 years. The history, clinical symptoms, audiological evaluation, high resolution temporal bone CT, the results of surgical exploration and hearing reconstruction were analyzed. RESULTS: The exploratory tympanotomy revealed 43 cases of congenital middle ear malformations (52.4%), 22 cases of otosclerosis (26.8%), eight cases of congenital cholesteatoma (9.8%), six cases of trauma induced conductive hearing loss (7.3%), three cases of congenital ossicular malformations with congenital cholesteatoma (3.7%). Progressive hearing loss was common in patients with otosclerosis and congenital cholesteatoma, and patients with congenital middle ear malformations described their hearing loss since childhood. High resolution temporal bone CT of congenital middle ear malformation, trauma induced conductive hearing loss, congenital cholesteatoma diagnosis rate was 40.0%, 50.0%, and 83.3% respectively. The preoperative air-conductive threshold of patients with absence of the oval window were increased to (66.9±1.1)dBHL, the preoperative bone-conductive threshold achieved (28.3±10.4)dBHL at 2 000 Hz. While patients with stapes fixation and that with ossicular chain discontinuity were (27.2±9.7)dBHL and (17.8±8.8)dBHL(P=0.000)respectively. Through the tympanic exploration with endaural incision under the microscope, different hearing reconstruction were applied according to different lesions. After the operation, the hearing level of 52 patients with return visit were improved, the mean air-conductive threshold were decreased from (60.0±11.4)dBHL to (32.2±12.1)dBHL(P=0.000); and the mean ABG were decreased from (43.2±12.0)dB to (16.3±9.4)dB(P=0.000). CONCLUSIONS: Congenital middle ear malformations, otosclerosis, congenital cholesteatoma are the most common causes in unilateral conductive hearing loss with an intact tympanic membrane. The diagnosis rate can be improved by analyzing the clinical features. Through exploratory tympanotomy and hearing reconstruction, we can clarify the diagnosis and achieve a satisfying hearing recover.