Detalhe da pesquisa
1.
Nanosurfer assay dissects ß-cardiac myosin and cardiac myosin-binding protein C interactions.
Biophys J
; 121(12): 2449-2460, 2022 06 21.
Artigo
Inglês
| MEDLINE | ID: mdl-35591788
2.
Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin.
Biophys J
; 120(11): 2222-2236, 2021 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33864791
3.
FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V.
J Biol Chem
; 295(51): 17383-17397, 2020 12 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33453985
4.
Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil.
J Biol Chem
; 294(46): 17314-17325, 2019 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31578282
5.
Converter domain mutations in myosin alter structural kinetics and motor function.
J Biol Chem
; 294(5): 1554-1567, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30518549
6.
Omecamtiv Mecarbil Enhances the Duty Ratio of Human ß-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle.
J Biol Chem
; 292(9): 3768-3778, 2017 03 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28082673
7.
Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region.
Nat Commun
; 15(1): 4359, 2024 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38777835
8.
Inter-filament co-operativity is crucial for regulating muscle contraction.
J Physiol
; 596(1): 17-18, 2018 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29143336
9.
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.
Nat Commun
; 13(1): 5222, 2022 09 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36064790
10.
Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.
Front Physiol
; 7: 659, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-28119616