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1.
Sensors (Basel) ; 20(18)2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32899881

RESUMO

Recently, the relationship between emotional arousal and depression has been studied. Focusing on this relationship, we first developed an arousal level voice index (ALVI) to measure arousal levels using the Interactive Emotional Dyadic Motion Capture database. Then, we calculated ALVI from the voices of depressed patients from two hospitals (Ginza Taimei Clinic (H1) and National Defense Medical College hospital (H2)) and compared them with the severity of depression as measured by the Hamilton Rating Scale for Depression (HAM-D). Depending on the HAM-D score, the datasets were classified into a no depression (HAM-D < 8) and a depression group (HAM-D ≥ 8) for each hospital. A comparison of the mean ALVI between the groups was performed using the Wilcoxon rank-sum test and a significant difference at the level of 10% (p = 0.094) at H1 and 1% (p = 0.0038) at H2 was determined. The area under the curve (AUC) of the receiver operating characteristic was 0.66 when categorizing between the two groups for H1, and the AUC for H2 was 0.70. The relationship between arousal level and depression severity was indirectly suggested via the ALVI.


Assuntos
Nível de Alerta , Transtorno Depressivo Maior , Reconhecimento de Voz , Adulto , Idoso , Depressão/diagnóstico , Transtorno Depressivo Maior/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Índice de Gravidade de Doença , Adulto Jovem
2.
Psychiatry Clin Neurosci ; 73(2): 77-83, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30506835

RESUMO

AIM: The importance of family care during international deployment is emphasized within military organizations, but mental health interactions between deployed personnel and their spouses have not yet been assessed. This study addressed this gap by examining couples' mental health throughout a deployment period. METHODS: The mental health of 324 spousal dyads of Japan Self-Defense Forces personnel dispatched for a half-year United Nations Disengagement Observer Force mission was examined, using longitudinal data derived from a survey at four time points: one-month pre-deployment, initial deployment, middle deployment, and immediately after homecoming. The 30-item General Health Questionnaire was used to evaluate general psychological distress, with high scores (≥7) indicating adverse mental health. RESULTS: The spouses' general psychological distress was significantly higher compared with the deployed personnel (P < 0.001). The high general psychological distress of personnel was significantly related to that of their spouses (odds ratio = 2.24; 95% confidence interval, 1.32-3.80), and vice versa (odds ratio = 2.38; 95% confidence interval 1.39-4.08). CONCLUSION: Mental health care will be beneficial for not only deployed personnel but also their spouses.


Assuntos
Militares/psicologia , Cônjuges/psicologia , Estresse Psicológico/psicologia , Adulto , Feminino , Humanos , Japão , Estudos Longitudinais , Masculino , Nações Unidas
3.
Biochem Biophys Res Commun ; 501(1): 307-312, 2018 06 18.
Artigo em Inglês | MEDLINE | ID: mdl-29738768

RESUMO

Life-threatening experiences can result in the development of post-traumatic stress disorder. We have developed an animal model for post-traumatic stress disorder (PTSD) using a shuttle box in rats. In this paradigm, the rats were exposed to inescapable foot-shock stress (IS) in a shuttle box, and then an avoidance/escape task was performed in the same box 2 weeks after IS. A previous study using this paradigm revealed that environmental enrichment (EE) ameliorated avoidance/numbing-like behaviors, but not hyperarousal-like behaviors, and EE also elevated hippocampal brain-derived neurotrophic factor (BDNF) expression. However, the differential effects of EE components, i.e., running wheel (RW) or toy rotation, on PTSD-like behaviors has remained unclear. In this experiment, we demonstrated that RW, toy rotation, and EE (containing RW and toy rotation) ameliorated avoidance/numbing-like behaviors, induced learning of avoidance responses, and improved depressive-like behaviors in traumatized rats. The RW increased the hippocampal mRNA expression of neurotrophic factors, especially BDNF and glial-cell derived neurotrophic factor. Toy rotation influenced FK506 binding protein 5 mRNA expression, which is believed to be a regulator of the hypothalamic-pituitary-adrenal (HPA)-axis system, in the hippocampus and amygdala. This is the first report to elucidate the differential mechanistic effects of RW and toy rotation. The former appears to exert its effects via neurotrophic factors, while the latter exerts its effects via the HPA axis. Further studies will lead to a better understanding of the influence of environmental factors on PTSD.


Assuntos
Fatores de Crescimento Neural/genética , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Transtornos de Estresse Pós-Traumáticos/genética , Transtornos de Estresse Pós-Traumáticos/metabolismo , Proteínas de Ligação a Tacrolimo/genética , Tonsila do Cerebelo/metabolismo , Animais , Aprendizagem da Esquiva , Comportamento Animal , Fator Neurotrófico Derivado do Encéfalo/genética , Modelos Animais de Doenças , Reação de Fuga , Fator Neurotrófico Derivado de Linhagem de Célula Glial/genética , Hipocampo/metabolismo , Sistema Hipotálamo-Hipofisário/metabolismo , Masculino , Atividade Motora , Fator de Crescimento Neural/genética , Sistema Hipófise-Suprarrenal/metabolismo , Córtex Pré-Frontal/metabolismo , Ratos , Ratos Wistar , Transtornos de Estresse Pós-Traumáticos/psicologia
4.
BMC Psychiatry ; 18(1): 328, 2018 10 11.
Artigo em Inglês | MEDLINE | ID: mdl-30309334

RESUMO

BACKGROUND: Disaster workers suffer from psychological distress not only through the direct experience of traumatic situations but also through the indirect process of aiding disaster victims. This distress, called secondary traumatic stress, is linked to dispositional empathy, which is the tendency for individuals to imagine and experience the feelings and experiences of others. However, the association between secondary traumatic stress and dispositional empathy remains understudied. METHODS: To examine the relationship between dispositional empathy and mental health among disaster workers, we collected data from 227 Japan Ground Self-Defense Force personnel who engaged in international disaster relief activities in the Philippines following Typhoon Yolanda in 2013. The Impact of Event Scale-Revised and the Kessler Psychological Distress Scale were used to evaluate posttraumatic stress responses (PTSR) and general psychological distress (GPD), respectively. Dispositional empathy was evaluated through the Interpersonal Reactivity Index, which consists of four subscales: Perspective Taking, Fantasy, Empathic Concern, and Personal Distress. Hierarchial linear regression analyses were performed to identify the variables related to PTSR and GPD. RESULTS: High PTSR was significantly associated with high Fantasy (identification tendency, ß = 0.21, p < .01), high Personal Distress (the self-oriented emotional disposition of empathy, ß = 0.18, p < .05), and no experience of disaster relief activities (ß = 0.15, p < .05). High GPD was associated with high Personal Distress (ß = 0.28, p < .001), marital status (married, ß = 0.22, p < .01), being female (ß = 0.18, p < .01), medical unit (ß = 0.18, p < .05), and no experience of disaster relief activities (ß = 0.13, p < .05). CONCLUSIONS: Among Japanese uniformed disaster workers, high PTSR was associated with two subtypes of dispositional empathy: the self-oriented emotional disposition of empathy and high identification tendency, whereas high GPD was associated with high identification tendency. Educational interventions that aim to mitigate these tendencies might be able to relieve the psychological distress of disaster workers.


Assuntos
Tempestades Ciclônicas , Desastres , Empatia , Exposição Ocupacional/efeitos adversos , Transtornos de Estresse Pós-Traumáticos/psicologia , Estresse Psicológico/psicologia , Adulto , Fadiga de Compaixão/epidemiologia , Fadiga de Compaixão/psicologia , Estudos Transversais , Empatia/fisiologia , Feminino , Humanos , Japão/epidemiologia , Masculino , Saúde Mental , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Estresse Psicológico/epidemiologia
5.
Biochem Biophys Res Commun ; 478(1): 424-430, 2016 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-27396623

RESUMO

Fatigue reduces productivity and is a risk factor for lifestyle diseases and mental disorders. Everyone experiences physiological fatigue and recovers with rest. Pathological fatigue, however, greatly reduces quality of life and requires therapeutic interventions. It is therefore necessary to distinguish between the two but there has been no biomarker for this. We report on the measurement of salivary human herpesvirus (HHV-) 6 and HHV-7 as biomarkers for quantifying physiological fatigue. They increased with military training and work and rapidly decreased with rest. Our results suggested that macrophage activation and differentiation were necessary for virus reactivation. However, HHV-6 and HHV-7 did not increase in obstructive sleep apnea syndrome (OSAS), chronic fatigue syndrome (CFS) and major depressive disorder (MDD), which are thought to cause pathological fatigue. Thus, HHV-6 and HHV-7 would be useful biomarkers for distinguishing between physiological and pathological fatigue. Our findings suggest a fundamentally new approach to evaluating fatigue and preventing fatigue-related diseases.


Assuntos
Síndrome de Fadiga Crônica/diagnóstico , Síndrome de Fadiga Crônica/virologia , Herpesvirus Humano 6/isolamento & purificação , Herpesvirus Humano 7/isolamento & purificação , Saliva/virologia , Adulto , Biomarcadores , Diagnóstico Diferencial , Humanos , Masculino , Militares , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Carga Viral/métodos
6.
BMC Psychiatry ; 16(1): 358, 2016 10 21.
Artigo em Inglês | MEDLINE | ID: mdl-27769203

RESUMO

BACKGROUND: Defense Force workers engaged in disaster relief activities might suffer from strong psychological stress due to the tasks that they had been involved. We evaluated how living environments, work environments, and individual factors psychologically affect those who engaged in disaster relief activities. METHOD: Data generated with 1506 personnel engaged in the Great East Japan Earthquake relief activity were analyzed. Those who scored ≥25 points on the Impact of Events Scale-Revised and the Kessler Psychological Distress Scale (K10) were allocated into the high post-traumatic stress response (high-PTSR) group, and the high general psychological distress (high-GPD) group, respectively. RESULTS: The multiple logistic regression analysis extracted living environment (camping within the shelter sites) as the significant risk factor for both high-PTSR (OR = 3.39, 95 % CI 2.04-5.64, p < 0.001) and high-GPD (OR = 3.35, 95 % CI 1.77-6.34, p < 0.001) groups. CONCLUSION: It is desirable for disaster workers to have a living environment in which they can keep an appropriate distance from the victims.


Assuntos
Desastres , Terremotos , Habitação , Transtornos Mentais/psicologia , Militares/psicologia , Local de Trabalho/psicologia , Adulto , Feminino , Humanos , Japão , Estudos Longitudinais , Masculino , Fatores de Risco , Transtornos de Estresse Pós-Traumáticos/psicologia , Estresse Psicológico/psicologia
7.
Seishin Shinkeigaku Zasshi ; 114(11): 1291-6, 2012.
Artigo em Japonês | MEDLINE | ID: mdl-23367839

RESUMO

We assessed the core factors necessary for mental health of disaster workers according to the following experiences: 1) the Japan Self-Defense Force (JSDF) disaster relief missions associated with the Great East Japan Earthquake and the Haiti peacekeeping deployment associated with the Great Haiti Earthquake, 2) conformations of the peacekeeping mission units of various countries deployed to Haiti, and 3) JSDF assistance activities to the Japanese earthquake victims. We learned that the basic life needs were the major premises for maintaining the mental health of the disaster workers. Food, drinking supplies, medical supplies were particularly crucial, yet overlooked in Japanese worker settings compared with forces of other countries. Conversely, the workers tend to feel guilty (moushi wake nai) for the victims when their basic life infrastructures are better than those of the victims. The Japanese workers and disaster victims both tend to find comfort in styles based on their culture, in particular, open-air baths and music performances. When planning workers' environments in disaster settings, provision of basic infrastructure should be prioritized, yet a sense of balance based on cultural background may be useful to enhance the workers' comfort and minimize their guilt.


Assuntos
Terremotos , Socorro em Desastres , Cuidadores/psicologia , Desastres , Haiti , Hospitais , Humanos , Japão , Saúde Mental , Estresse Psicológico/terapia
8.
Artigo em Inglês | MEDLINE | ID: mdl-34069609

RESUMO

BACKGROUND: In many developed countries, mood disorders have become problematic, and the economic loss due to treatment costs and interference with work is immeasurable. Therefore, a simple technique to determine individuals' depressive state and stress level is desired. METHODS: We developed a method to assess specific the psychological issues of individuals with major depressive disorders using emotional components contained in their voice. We propose two indices: vitality, a short-term index, and mental activity, a long-term index capturing trends in vitality. To evaluate our method, we used the voices of healthy individuals (n = 14) and patients with major depression (n = 30). The patients were also assessed by specialists using the Hamilton Rating Scale for Depression (HAM-D). RESULTS: A significant negative correlation existed between the vitality extracted from the voices and HAM-D scores (r = -0.33, p < 0.05). Furthermore, we could discriminate the voice data of healthy individuals and patients with depression with a high accuracy using the vitality indicator (p = 0.0085, area under the curve of the receiver operating characteristic curve = 0.76).


Assuntos
Transtorno Depressivo Maior , Afeto , Depressão , Transtorno Depressivo Maior/diagnóstico , Humanos , Transtornos do Humor , Escalas de Graduação Psiquiátrica
9.
Sci Rep ; 11(1): 13615, 2021 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-34193915

RESUMO

In this research, we propose a new index of emotional arousal level using sound pressure change acceleration, called the emotional arousal level voice index (EALVI), and investigate the relationship between this index and depression severity. First, EALVI values were calculated from various speech recordings in the interactive emotional dyadic motion capture database, and the correlation with the emotional arousal level of each voice was examined. The resulting correlation coefficient was 0.52 (n = 10,039, p < 2.2 × 10-16). We collected a total of 178 datasets comprising 10 speech phrases and the Hamilton Rating Scale for Depression (HAM-D) score of outpatients with major depression at the Ginza Taimei Clinic (GTC) and the National Defense Medical College (NDMC) Hospital. The correlation coefficients between the EALVI and HAM-D scores were - 0.33 (n = 88, p = 1.8 × 10-3) and - 0.43 (n = 90, p = 2.2 × 10-5) at the GTC and NDMC, respectively. Next, the dataset was divided into "no depression" (HAM-D < 8) and "depression" groups (HAM-D ≥ 8) according to the HAM-D score. The number of patients in the "no depression" and "depression" groups were 10 and 78 in the GTC data, and 65 and 25 in the NDMC data, respectively. There was a significant difference in the mean EALVI values between the two groups in both the GTC and NDMC data (p = 8.9 × 10-3, Cliff's delta = 0.51 and p = 1.6 × 10-3; Cliff's delta = 0.43, respectively). The area under the curve of the receiver operating characteristic curve when discriminating both groups by EALVI was 0.76 in GTC data and 0.72 in NDMC data. Indirectly, the data suggest that there is some relationship between emotional arousal level and depression severity.


Assuntos
Nível de Alerta , Bases de Dados Factuais , Depressão/fisiopatologia , Transtorno Depressivo Maior/fisiopatologia , Emoções , Voz , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença
10.
JAMA Netw Open ; 3(9): e2018339, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32990742

RESUMO

Importance: First responders are at risk for developing symptoms of posttraumatic stress disorder (PTSD). Little is known about the risk factors for developing PTSD during a years-long period after complex mass disasters. Objective: To explore the long-term course of PTSD symptoms and to identify risk factors and their relative association with PTSD among first responders dispatched to the 2011 Japanese earthquake, tsunami, and nuclear disaster. Design, Setting, and Participants: This 6-year, large, prospective cohort study was part of a continuous longitudinal study of Japan Ground Self-Defense Force first responders. The data were collected at 1, 6, 12, 24, 36, 48, 60, and 72 months after mission completion from 2011 to 2017. Of approximately 70 000 eligible participants, 56 388 were enrolled in this study. Data were analyzed from 2017 to 2020. Exposures: Stress exposures owing to personal or professional disaster experience (eg, duties with body recovery or radiation exposure risk) and working conditions (eg, deployment length, postdeployment overtime work). Main Outcomes and Measures: The Impact of Event Scale-Revised score assessed PTSD symptoms; scores of at least 25 were defined as probable PTSD. Cox proportional hazards regression models assessed the risk factors for incidence of probable PTSD. Results: Among the 56 388 participants, 97.1% were men, and the median age at enrollment was 34 (range, 18-63) years. A probable PTSD rate was 2.7% at 1 month and showed a downward trend in the first year and a subsequent plateau. The cumulative incidence of probable PTSD was 6.75%. The severity of PTSD symptoms demonstrated a high degree of rank-order stability over time. Rather than professional disaster experience, sociodemographic factors and working conditions were independently associated with the incidence of probable PTSD: personal experience of the disaster (hazard ratio [HR], 1.96; 95% CI, 1.72-2.24), deployment length of at least 3 months (HR vs <1 month, 1.75; 95% CI, 1.52-2.02), increased age (HR for ≥46 vs ≤25 years, 2.28; 95% CI, 1.79-2.92), and postdeployment overtime work of at least 3 months (HR vs little to none, 1.61; 95% CI, 1.39-1.87). Conclusions and Relevance: Given these findings, in the future, first responders' PTSD symptoms might be mitigated by shortening deployment length, avoiding postdeployment overtime work, and paying special attention to the needs of personnel with personal experience of the disaster or older age. Efforts to alleviate responders' initial symptoms will be required.


Assuntos
Desastres , Terremotos , Socorristas/estatística & dados numéricos , Doenças Profissionais/epidemiologia , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Adolescente , Adulto , Fatores Etários , Feminino , Humanos , Incidência , Japão/epidemiologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/psicologia , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fatores de Risco , Fatores Socioeconômicos , Transtornos de Estresse Pós-Traumáticos/psicologia , Fatores de Tempo , Adulto Jovem
11.
J Affect Disord ; 272: 417-422, 2020 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-32553385

RESUMO

BACKGROUND: Child abuse is a risk factor for mood disorders, and linked to decreased DNA methylation (DNAm) of FKBP5 intron 7 through interactions with the single nucleotide polymorphism (SNP) rs1360780. However, no study has investigated which specific subtypes of child abuse are related to decreased DNAm of FKBP5 intron 7 in mood disorders. We therefore aimed to examine the relationship among various subtypes of child abuse, rs1360780, and the DNAm level of FKBP5 intron 7. METHODS: A total of 190 subjects (87 patients with major depressive disorder [MDD], 61 patients with bipolar disorder [BD], and 42 healthy controls) participated. The Child Abuse and Trauma Scale (CATS) was used to evaluate child abuse. Whole blood was processed for genotyping, and pyrosequencing was conducted to assess the DNAm level of FKBP5 intron 7. A multiple regression analysis was used to analyze the DNAm level as a dependent variable, and the CATS subtypes and rs1360780 were used as independent variables. RESULTS: Emotional abuse/neglect, one of the specific subtypes of child abuse, was related to lower DNAm of FKBP5 intron 7 interacting with rs1360780 in the BD patients. There were no significant results in the MDD patients or the controls. LIMITATIONS: Since the study was limited to Japanese individuals, particularly those with MDD and BD, the findings are not generalizable. Furthermore, as child abuse was measured retrospectively, there may be recall bias. CONCLUSIONS: This finding indicates that a specific subtype of child abuse may play an important role in the development of BD.


Assuntos
Transtorno Bipolar , Maus-Tratos Infantis , Transtorno Depressivo Maior , Transtorno Bipolar/genética , Criança , Metilação de DNA/genética , Transtorno Depressivo Maior/genética , Genótipo , Humanos , Polimorfismo de Nucleotídeo Único/genética , Estudos Retrospectivos , Proteínas de Ligação a Tacrolimo/genética
12.
Eur J Pharmacol ; 865: 172751, 2019 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-31654623

RESUMO

Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder, characterized by bi-directional symptomatic manifestations of increase in both hyperarousal/hypervigilance and numbing/avoidance. In our previous reports, we have proposed an animal model of PTSD using avoidance/escape task sessions in the shuttle box after delivering an inescapable foot-shock traumatization in the same box (Wakizono et al., 2007), and demonstrated the efficacy of 2-week administration of antidepressant on the hyperarousal/hypervigilant behavioral parameters (Sawamura et al., 2004) in the model. In this study, we observed a partial but significant efficacy of oral supplementation of eicosapentaenoic acid (EPA) for five weeks on the numbing/avoidance behavior in the experimental model. Additionally, western blot analyses using brain-derived neurotrophic factor (BDNF) monoclonal antibody revealed a decreased expression of BDNF protein, in the hippocampal region of the rats, due to foot-shock traumatization and a significantly increased expression of BDNF protein after oral EPA supplementation. The results indicate a possibility that alteration of the numbing/avoidance behavior parallels the expression of hippocampal BDNF in the rat brain. The present study suggests a possibility that EPA supplementation in the treatment of PTSD ameliorates persistent numbing/avoidance symptoms. (185 words).


Assuntos
Fator Neurotrófico Derivado do Encéfalo/metabolismo , Suplementos Nutricionais , Ácido Eicosapentaenoico/farmacologia , Hipocampo/efeitos dos fármacos , Transtornos de Estresse Pós-Traumáticos/metabolismo , Animais , Aprendizagem da Esquiva/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Modelos Animais de Doenças , Hipocampo/metabolismo , Masculino , Ratos Wistar
13.
J Affect Disord ; 257: 396-403, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31306990

RESUMO

BACKGROUND: We previously reported that child abuse indirectly predicts the diagnosis of major depressive disorder (MDD) or bipolar disorder (BP) based on higher scores of affective temperaments; however, the subtypes of child abuse have not been examined sufficiently. Therefore, in the present study, we used the reclassified version of the Child Abuse and Trauma Scale (CATS) to determine how the subtypes of child abuse affect affective temperaments. METHODS: A total of 502 participants (212 healthy controls, 163 patients with MDD and 127 patients with BP) were administered the Japanese version of the CATS; the Japanese version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire; and the Japanese version of the Patient Health Questionnaire-9. Data were analyzed by exploratory and confirmatory factor analyses, as well as by univariate and multivariate analyses. RESULTS: A five-factor structure was appropriate for the CATS. The MDD group scored significantly higher on all subtypes of the reclassified CATS than did the control group. Among the subscales of the reclassified CATS, physical abuse and loneliness/psychological stress were significant predictors of affective temperaments, although all subscales were significantly associated with affective temperaments compared to the original CATS. LIMITATIONS: Since child abuse was assessed retrospectively, there might be recall bias. Furthermore, as the study was limited to Japanese individuals, particularly those with mood disorders, the findings might not be generalizable. CONCLUSIONS: This study revealed that the subtypes of child abuse (especially physical abuse and loneliness/psychological stress) might be associated with MDD and BP.


Assuntos
Sobreviventes Adultos de Maus-Tratos Infantis/estatística & dados numéricos , Transtorno Bipolar/psicologia , Maus-Tratos Infantis/classificação , Maus-Tratos Infantis/psicologia , Transtorno Depressivo Maior/psicologia , Temperamento , Adulto , Estudos de Casos e Controles , Criança , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Inquéritos e Questionários
14.
J Occup Environ Med ; 61(1): 69-74, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30335679

RESUMO

OBJECTIVES: The aim of this study was to predict increased alcohol and tobacco use in Fukushima nuclear power plant (NPP) workers 3 years after a nuclear disaster. METHODS: Surveys were conducted in two postdisaster waves (Wave 1: 2 to 3 months; Wave 2: 32 months). Adjusted risk ratio (aRR) was computed to assess the covariates of increased alcohol and tobacco use in Wave 2. RESULTS: Increased alcohol use was associated with age of 29 years or less [aRR (95% confidence interval (95% CI): 1.26 (1.01 to 1.57)], major property loss [1.25 (95% CI 1.02 to 1.55)], and high posttraumatic stress responses (PTSRs) [1.34 (95% CI 1.08 to 1.67)] in Wave 1. Increased tobacco use was associated with age of 29 years or less [1.46 (95% CI 1.12 to 1.90)] and high PTSR [1.62 (95% CI 1.25 to 2.10)] in Wave 1 (P < 0.05). CONCLUSION: The workers' increased alcohol and tobacco use were predicted by major property loss (alcohol), age of 29 years or less, and high PTSR (alcohol/tobacco) in Wave 1.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Acidente Nuclear de Fukushima , Uso de Tabaco/epidemiologia , Adulto , Feminino , Humanos , Estudos Longitudinais , Masculino , Razão de Chances , Transtornos de Estresse Pós-Traumáticos/complicações , Transtornos de Estresse Pós-Traumáticos/etiologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Inquéritos e Questionários
15.
Gut Liver ; 13(3): 325-332, 2019 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-30602220

RESUMO

Background/Aims: Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut microbiota in brain-gut axis pathogenesis during coincident depression and IBS. Methods: Rat models of depression were induced using our shuttle box method of learned helplessness. Visceral hypersensitivity was evaluated by colorectal distension (CRD) to diagnose IBS. Gut microbiota compositions were analyzed using high-throughput sequencing. In the subanalysis of rats without depression-like symptoms, rats with posttraumatic stress disorder (PTSD) were also examined. Results: The threshold value of CRD in depressed rats was significantly lower than that in control rats. Microbial community analysis of cecal microbiota showed that the relative abundance of Clostridiales incertae sedis, the most prevalent microbe, was significantly lower in depressed rats than in control rats. The distribution pattern of the microbiota clearly differed between depressed rats and control rats. Neither visceral hypersensitivity nor the composition of gut microbiota was altered in rats with PTSD-like phenotypes. Conclusions: Our rat model of depression is useful for clarifying the effect of depression on IBS and suggests that depression itself, rather than specific stressors, promotes the onset of IBS. Further, we provided evidence that various psychiatric diseases, viz., depression and PTSD, are associated with unique gut microbiota profiles, which could differentially affect the onset and progression of coincident IBS.


Assuntos
Depressão/microbiologia , Disbiose/psicologia , Síndrome do Intestino Irritável/microbiologia , Síndrome do Intestino Irritável/psicologia , Animais , Modelos Animais de Doenças , Microbioma Gastrointestinal , Masculino , Ratos , Ratos Wistar
16.
Neuropsychiatr Dis Treat ; 14: 2505-2510, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30323599

RESUMO

PURPOSE: The importance of resilience as a mental health outcome has been reported in recent occupational health studies, although resilience is yet to be assessed in the Japan Ground Self-Defense Force (JGSDF) population. Our objective was to test whether the Tachikawa Resilience Scale (TRS), developed to measure the resilience of Japanese individuals, is useful for evaluating the resilience of the JGSDF. PATIENTS AND METHODS: We performed a cross-sectional study of 353 JGSDF peacekeeping personnel engaged in the United Nations Mission in the Republic of South Sudan from November 2015 to May 2016. We evaluated resilience using two psychological measures: the TRS and the Resilience Competence Scale - Japanese Short Version (RCS-JS). To verify the construct validity of the TRS, we performed exploratory factor analysis and confirmatory factor analysis. We subsequently conducted hierarchical multivariate regression analysis to evaluate the relationship of the TRS and the RCS-JS with psychological distress measured by the Japanese version of the Kessler Psychological Distress Scale. RESULTS: Of those recruited, 281 (79.6%) agreed to participate. The exploratory factor analysis revealed a one-factor model of the TRS. The confirmatory factor analysis model showed good fit (ratio of χ 2 to the degrees of freedom =1.409, P=0.105, comparative fit index =0.994, root mean square error of approximation =0.038). Both the TRS and the RCS-JS showed a significant inverse correlation with the Kessler Psychological Distress Scale, and the regression coefficient of the TRS was equivalent to that of the RCS-JS. CONCLUSION: We confirmed the construct validity and reliability of the TRS when applied to the JGSDF, and demonstrated the usefulness of the TRS in this population.

17.
Psychiatry Res ; 262: 13-19, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29407563

RESUMO

In previous studies, various components such as environmental and genetic factors have been shown to contribute to the development of bipolar disorder (BD). This study investigated how multiple factors, including child abuse, adult life events, and affective temperaments, are interrelated and how they affect the diagnosis of BD. A total of 170 healthy controls and 75 BD patients completed the following self-administered questionnaires: the Patient Health Questionnaire-9 evaluating the severity of depressive symptoms; the Child Abuse and Trauma Scale (CATS) evaluating child abuse; the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS-A) evaluating affective temperaments; and the Life Experiences Survey (LES) evaluating negative and positive adult life events. The data were subjected to univariate analysis, multivariable analysis, and structural equation modeling. The structural equation modeling showed that the diagnosis of BD was indirectly predicted by the neglect and sexual abuse scores of the CATS through four affective temperaments (depressive, cyclothymic, irritable, and anxious) of the TEMPS-A and directly predicted by these four affective temperaments. This study suggested that affective temperament plays an important role as a mediator in the influence of child abuse on BD diagnosis.


Assuntos
Sobreviventes Adultos de Maus-Tratos Infantis/psicologia , Afeto , Transtorno Bipolar/psicologia , Acontecimentos que Mudam a Vida , Temperamento , Adulto , Estudos de Casos e Controles , Depressão/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Autorrelato
18.
Psychiatry ; 81(3): 288-296, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29485350

RESUMO

OBJECTIVE: Approximately 70,000 Japan Ground Self-Defense Force (JGSDF) personnel were dispatched in the wake of the 2011 Great East Japan Earthquake and the tsunami and nuclear disaster that followed. This study was conducted to evaluate the mental health of the JGSDF personnel and the correlates. METHODS: Data collected from 56,753 participants at three time points (one, six, and 12 months after mission completion) were analyzed. Those who scored 25 or more points on the Impact of Events Scale-Revised (IES-R) and the Kessler Psychological Distress Scale (K10) were allocated into the high posttraumatic stress response (high-PTSR) group, and the high general psychological distress (high-GPD) group, respectively. RESULTS: The multiple logistic regression analysis identified the following factors as the significant risk factor related to high-PTSR or high-GPD status, with odds ratios of 2.0 or higher: deployment length of three or more months, being personally affected by the disaster, and being overworked continuously for three or more months after mission completion. No significant association was observed for duties with radiation exposure risk. CONCLUSIONS: Our findings suggest that disaster workers may be able to conduct disaster relief activities more safely with mission-related considerations of shorter deployment length and recognizing the effects on personnel personally affected by the disaster, in addition to avoiding overworking personnel after mission completion.


Assuntos
Terremotos , Acidente Nuclear de Fukushima , Militares/estatística & dados numéricos , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Estresse Psicológico/epidemiologia , Tsunamis , Adulto , Feminino , Humanos , Japão/epidemiologia , Estudos Longitudinais , Masculino , Fatores de Risco
19.
Psychiatry ; 81(1): 85-92, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29494786

RESUMO

OBJECTIVE: To evaluate the correlates of psychological responses in dentists who conducted disaster victim identification (DVI) in Fukushima following the 2011 earthquake/tsunami/nuclear disaster. METHOD: Self-report questionnaires were administered to 49 male dentists six to nine months after the disaster. Psychological distress and posttraumatic stress were measured using the General Health Questionnaire-30 (GHQ-30) and Impact of Event Scale-Revised (IES-R), respectively. Independent variables included sociodemographic characteristics, participant disaster exposures, DVI-related exposures, and fear of radiation exposure during DVI. Hierarchical multiple regression analysis was performed to examine independent-dependent variable relations. RESULTS: Thirty-eight participants (77.6%) had examined ≥ 40 corpses, 20 (40.8%) reported ≥ 4 corpse-related exposures, and six (12.2%) reported ≥ 5 gruesome corpse exposures. Mean (SD) GHQ-30 and IES-R scores were 5.08 (5.31) and 9.90 (10.1), respectively. Higher levels of psychological distress were associated with younger age (adjusted ß = -0.29), extensive property loss (ß = 0.34), and anxiety for the future (ß = 0.33). Higher levels of posttraumatic stress were associated with extensive property loss (adjusted R2 = 17.7%, ß = 0.30). Neither outcome was associated with DVI-related exposures or fear of radiation exposure during DVI (p < 0.05). CONCLUSIONS: Dentists' psychological burden was associated with disaster, but not DVI, exposures.


Assuntos
Odontólogos/psicologia , Vítimas de Desastres/classificação , Acidente Nuclear de Fukushima , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Estresse Psicológico/epidemiologia , Adulto , Fatores Etários , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade
20.
BJPsych Open ; 2(2): e3-e4, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27703775

RESUMO

SUMMARY: United Nations peacekeeping personnel face numerous stressors due to their challenging deployments. Past studies have had inconsistent results regarding whether or not their deployment experience affects their mental health outcomes. Further studies are required to ascertain the associations between their outcomes and factors before, during and after their peacekeeping missions. DECLARATIONS OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.

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