Detalhe da pesquisa
1.
Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg Med Chem Lett
; 29(6): 786-790, 2019 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30728114
2.
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
Bioorg Med Chem Lett
; 27(13): 2990-2995, 2017 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28522253
3.
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides.
Bioorg Med Chem Lett
; 27(23): 5179-5184, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29089231
4.
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
Bioorg Med Chem Lett
; 27(2): 171-175, 2017 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27939174
5.
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
Bioorg Med Chem Lett
; 26(17): 4282-6, 2016 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27476142
6.
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Bioorg Med Chem Lett
; 26(13): 3029-3033, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27185330
7.
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.
Bioorg Med Chem Lett
; 23(2): 412-6, 2013 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23237839
8.
Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.
Bioorg Med Chem Lett
; 23(1): 223-7, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23200253
9.
Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184].
Bioorg Med Chem Lett
; 28(17): 3014, 2018 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30076050
10.
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
Bioorg Med Chem Lett
; 22(10): 3467-72, 2012 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22507963
11.
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.
Bioorg Med Chem Lett
; 21(21): 6451-5, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21930376
12.
Lanthanum tricyanide-catalyzed acyl silane-ketone benzoin additions and kinetic resolution of resultant alpha-silyloxyketones.
J Org Chem
; 75(10): 3317-25, 2010 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-20392127
13.
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
J Med Chem
; 62(8): 3971-3988, 2019 04 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30929420
14.
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
J Med Chem
; 61(6): 2410-2421, 2018 03 22.
Artigo
Inglês
| MEDLINE | ID: mdl-29323899
15.
Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
FEBS Lett
; 591(1): 240-251, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27878989
16.
Monitoring the speciation of aqueous free chlorine from pH 1 to 12 with Raman spectroscopy to determine the identity of the potent low-pH oxidant.
Appl Spectrosc
; 60(7): 764-72, 2006 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-16854264
17.
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
J Med Chem
; 59(5): 2054-66, 2016 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26878343
18.
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.
ACS Chem Neurosci
; 5(10): 920-42, 2014 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25137629
19.
Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100.
Neuropsychopharmacology
; 39(7): 1578-93, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24442096
20.
Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease.
Drug Discov Today
; 18(23-24): 1185-99, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24051397