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1.
Issues Ment Health Nurs ; 45(6): 617-623, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38593452

RESUMO

Pre-registration nursing education has long moved away from preparing nurses with mental health specialisation to nurses with comprehensive knowledge and skills. However, the consumers' experiences of comprehensive-prepared nurses and their nursing care has not been widely explored. This paper reports on a study with consumers to explore their experiences with comprehensive-prepared graduate nurses and the nursing care that they provide in acute mental health settings. An exploratory qualitative study using semi-structured interviews was chosen as the research method. Purposeful sampling recruited 12 consumers and data saturation was achieved. Braun and Clarke's method of thematic analysis was used to analyse the collected data and three themes emerged. The themes are: (i) You got what it takes to be a mental health nurse, (ii) Slow down and spend quality time with us, and (iii) Read in between the lines when we share our negative lived experiences. The findings are useful for identifying strategies to develop evidence-based nursing education for comprehensive-prepared graduate nurses to improve the consumers' experiences of their nursing care.


Assuntos
Enfermagem Psiquiátrica , Pesquisa Qualitativa , Humanos , Masculino , Adulto , Feminino , Enfermagem Psiquiátrica/educação , Pessoa de Meia-Idade , Educação de Pós-Graduação em Enfermagem , Transtornos Mentais/enfermagem , Satisfação do Paciente
2.
Hum Mol Genet ; 26(8): 1472-1482, 2017 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-28186563

RESUMO

SOX5 encodes a transcription factor that is expressed in multiple tissues including heart, lung and brain. Mutations in SOX5 have been previously found in patients with amyotrophic lateral sclerosis (ALS) and developmental delay, intellectual disability and dysmorphic features. To characterize the neuronal role of SOX5, we silenced the Drosophila ortholog of SOX5, Sox102F, by RNAi in various neuronal subtypes in Drosophila. Silencing of Sox102F led to misorientated and disorganized michrochaetes, neurons with shorter dendritic arborization (DA) and reduced complexity, diminished larval peristaltic contractions, loss of neuromuscular junction bouton structures, impaired olfactory perception, and severe neurodegeneration in brain. Silencing of SOX5 in human SH-SY5Y neuroblastoma cells resulted in a significant repression of WNT signaling activity and altered expression of WNT-related genes. Genetic association and meta-analyses of the results in several large family-based and case-control late-onset familial Alzheimer's disease (LOAD) samples of SOX5 variants revealed several variants that show significant association with AD disease status. In addition, analysis for rare and highly penetrate functional variants revealed four novel variants/mutations in SOX5, which taken together with functional prediction analysis, suggests a strong role of SOX5 causing AD in the carrier families. Collectively, these findings indicate that SOX5 is a novel candidate gene for LOAD with an important role in neuronal function. The genetic findings warrant further studies to identify and characterize SOX5 variants that confer risk for AD, ALS and intellectual disability.


Assuntos
Doença de Alzheimer/genética , Esclerose Lateral Amiotrófica/genética , Deficiências do Desenvolvimento/genética , Proteínas de Drosophila/genética , Fatores de Transcrição SOXD/genética , Doença de Alzheimer/patologia , Esclerose Lateral Amiotrófica/patologia , Animais , Deficiências do Desenvolvimento/patologia , Drosophila/genética , Inativação Gênica , Estudos de Associação Genética , Humanos , Junção Neuromuscular/genética , Junção Neuromuscular/patologia , Plasticidade Neuronal/genética , Neurônios/metabolismo , Neurônios/patologia , Interferência de RNA , Via de Sinalização Wnt/genética
3.
J Pediatr Orthop B ; 24(1): 50-5, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25305046

RESUMO

Reconstruction of the distal femur after resection for primary bone tumour in very young patients presents a considerable challenge. The risks and benefits of the available reconstructive options need to be carefully balanced. We report a case of osteosarcoma of the distal femur in a 4-year-old boy that was, unusually, treated by amputation and a tibial turn-up procedure; we discuss the rationale for the procedure and report the results at early follow-up.


Assuntos
Neoplasias Femorais/cirurgia , Osteossarcoma/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Tíbia/cirurgia , Amputação Cirúrgica , Pré-Escolar , Humanos , Masculino , Procedimentos Ortopédicos/métodos , Resultado do Tratamento
4.
PLoS One ; 10(9): e0137236, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26348211

RESUMO

Circadian rhythms are endogenous, entrainable oscillations of physical, mental and behavioural processes in response to local environmental cues such as daylight, which are present in the living beings, including humans. Circadian rhythms have been related to cardiovascular function and pathology. However, the role that circadian clock genes play in heart development and function in a whole animal in vivo are poorly understood. The Drosophila cryptochrome (dCry) is a circadian clock gene that encodes a major component of the circadian clock negative feedback loop. Compared to the embryonic stage, the relative expression levels of dCry showed a significant increase (>100-fold) in Drosophila during the pupa and adult stages. In this study, we utilized an ultrahigh resolution optical coherence microscopy (OCM) system to perform non-invasive and longitudinal analysis of functional and morphological changes in the Drosophila heart throughout its post-embryonic lifecycle for the first time. The Drosophila heart exhibited major morphological and functional alterations during its development. Notably, heart rate (HR) and cardiac activity period (CAP) of Drosophila showed significant variations during the pupa stage, when heart remodeling took place. From the M-mode (2D + time) OCM images, cardiac structural and functional parameters of Drosophila at different developmental stages were quantitatively determined. In order to study the functional role of dCry on Drosophila heart development, we silenced dCry by RNAi in the Drosophila heart and mesoderm, and quantitatively measured heart morphology and function in those flies throughout its development. Silencing of dCry resulted in slower HR, reduced CAP, smaller heart chamber size, pupal lethality and disrupted posterior segmentation that was related to increased expression of a posterior compartment protein, wingless. Collectively, our studies provided novel evidence that the circadian clock gene, dCry, plays an essential role in heart morphogenesis and function.


Assuntos
Relógios Circadianos/genética , Criptocromos/genética , Proteínas de Drosophila/genética , Proteínas do Olho/genética , Coração/crescimento & desenvolvimento , Morfogênese/genética , Animais , Criptocromos/biossíntese , Drosophila/genética , Drosophila/crescimento & desenvolvimento , Drosophila/ultraestrutura , Proteínas de Drosophila/biossíntese , Proteínas do Olho/biossíntese , Regulação da Expressão Gênica no Desenvolvimento , Inativação Gênica , Humanos , Microscopia , Miocárdio/ultraestrutura , Pupa
5.
Bull NYU Hosp Jt Dis ; 66(1): 65-7, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18333832

RESUMO

Malalignment is associated with an increased rate of loosening of knee prostheses. We present a case of primary knee replacement failure due to pre-existing tibial deformity. Correction of the deformity and associated malalignment was undertaken using the Ilizarov osteotomy method prior to full knee revision surgery.


Assuntos
Artroplastia do Joelho , Fixadores Externos , Fraturas Mal-Unidas/cirurgia , Técnica de Ilizarov/instrumentação , Osteoartrite do Joelho/cirurgia , Fraturas da Tíbia/cirurgia , Idoso , Feminino , Fraturas Mal-Unidas/complicações , Humanos , Osteoartrite do Joelho/complicações , Reoperação , Fraturas da Tíbia/complicações
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