Detalhe da pesquisa
1.
A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia.
Mol Med
; 22: 338-348, 2016 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-27496104
2.
Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations.
J Pain
; 24(2): 204-225, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36198371
3.
Design of Phase 3 Studies Evaluating Vixotrigine for Treatment of Trigeminal Neuralgia.
J Pain Res
; 13: 1601-1609, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32669869
4.
Evaluation of the Pharmacokinetic Interaction Between the Voltage- and Use-Dependent Nav1.7 Channel Blocker Vixotrigine and Carbamazepine in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 9(1): 62-73, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31650711
5.
Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia.
ACS Med Chem Lett
; 11(9): 1678-1687, 2020 Sep 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32945812
6.
Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience.
Trials
; 19(1): 704, 2018 Dec 27.
Artigo
Inglês
| MEDLINE | ID: mdl-30587219
7.
The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.
J Neurosci
; 26(50): 12852-60, 2006 Dec 13.
Artigo
Inglês
| MEDLINE | ID: mdl-17167076
8.
Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.
Lancet Neurol
; 16(4): 291-300, 2017 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-28216232
9.
Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
J Neurosci
; 25(47): 10970-80, 2005 Nov 23.
Artigo
Inglês
| MEDLINE | ID: mdl-16306410
10.
A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy.
Pain
; 157(10): 2297-2308, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27322439
11.
The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models.
Pain
; 96(3): 269-277, 2002 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-11972999
12.
Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23.
Neuropharmacology
; 46(3): 425-38, 2004 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-14975698
13.
Expression of the sodium channel beta3 subunit in injured human sensory neurons.
Neuroreport
; 15(10): 1629-32, 2004 Jul 19.
Artigo
Inglês
| MEDLINE | ID: mdl-15232296
14.
Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.
Neuroreport
; 14(2): 191-5, 2003 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-12598727
15.
Differential expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 in normal and inflamed rats.
Neurosci Lett
; 355(1-2): 45-8, 2004 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-14729231
16.
Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum.
Naunyn Schmiedebergs Arch Pharmacol
; 369(6): 602-15, 2004 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15127180
17.
Multiple mechanisms have been tested in pain--how can we improve the chances of success?
Curr Opin Pharmacol
; 14: 11-7, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24565006
18.
Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia.
Trials
; 14: 402, 2013 Nov 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24267010
19.
Transient receptor potential channels: targeting pain at the source.
Nat Rev Drug Discov
; 8(1): 55-68, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19116627
20.
Nav(1.8)igating the maze of sensory function.
Pain
; 153(10): 1985-1986, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22738797