Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Mais filtros

Base de dados
Tipo de documento
Intervalo de ano de publicação
1.
Front Zool ; 11: 48, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24872836

RESUMO

INTRODUCTION: Urbanization is a global phenomenon that is encroaching on natural habitats and decreasing biodiversity, although it is creating new habitats for some species. The Eurasian kestrel (Falco tinnunculus) is frequently associated with urbanized landscapes but it is unclear what lies behind the high densities of kestrels in the urban environment. RESULTS: Occupied nest sites in the city of Vienna, Austria were investigated along a gradient of urbanization (percentage of land covered by buildings or used by traffic). Field surveys determined the abundance of potential prey (birds and rodents) and the results were compared to the birds' diets. A number of breeding parameters were recorded over the course of three years. The majority of kestrels breed in semi-natural cavities in historic buildings. Nearest neighbour distances (NND) were smallest and reproductive success lowest in the city centre. Abundance of potential prey was not found to relate to the degree of urbanization but there was a significant shift in the birds' diets from a heavy reliance on rodents in the outskirts of the city to feeding more on small birds in the centre. The use of urban habitats was associated with higher nest failure, partly associated with predation and nest desertion, and with significantly lower hatching rates and smaller fledged broods. CONCLUSIONS: High breeding densities in urban habitats do not necessarily correlate with high habitat quality. The high density of kestrel nests in the city centre is probably due to the ready availability of breeding cavities. Highly urbanized areas in Vienna are associated with unexpected costs for the city dwelling-raptor, in terms both of prey availability and of reproductive success. The kestrel appears to be exploiting the urban environment but given the poor reproductive performance of urban kestrels it is likely that the species is falling into an ecological trap.

2.
Cancers (Basel) ; 12(1)2020 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-31936322

RESUMO

We review the history of the tyrosine kinase 2 (TYK2) as the founding member of the Janus kinase (JAK) family and outline its structure-function relation. Gene-targeted mice and hereditary defects of TYK2 in men have established the biological and pathological functions of TYK2 in innate and adaptive immune responses to infection and cancer and in (auto-)inflammation. We describe the architecture of the main cytokine receptor families associated with TYK2, which activate signal transducers and activators of transcription (STATs). We summarize the cytokine receptor activities with well characterized dependency on TYK2, the types of cells that respond to cytokines and TYK2 signaling-induced cytokine production. TYK2 may drive beneficial or detrimental activities, which we explain based on the concepts of tumor immunoediting and the cancer-immunity cycle in the tumor microenvironment. Finally, we summarize current knowledge of TYK2 functions in mouse models of tumor surveillance. The biology and biochemistry of JAKs, TYK2-dependent cytokines and cytokine signaling in tumor surveillance are well covered in recent reviews and the oncogenic properties of TYK2 are reviewed in the recent Special Issue 'Targeting STAT3 and STAT5 in Cancer' of Cancers.

3.
Curr Biol ; 15(2): R36-7, 2005 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-15668147

RESUMO

The European Commission recently announced the launch of PathoGenoMics, to coordinate funding for research on disease-causing microbes. Graham Tebb reports.


Assuntos
Bactérias/genética , Doenças Transmissíveis/economia , Apoio à Pesquisa como Assunto/legislação & jurisprudência , Antibacterianos , Desenho de Fármacos , União Europeia , Genômica/tendências , Cooperação Internacional , Farmacogenética/tendências , Apoio à Pesquisa como Assunto/organização & administração
4.
Curr Biol ; 14(19): R821-4, 2004 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-15458654

RESUMO

Researchers from a small European country have backed a project set up ten years ago in Costa Rica that has now become a major influence in conservation and research.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Árvores , Costa Rica , Pesquisa , Clima Tropical
5.
Curr Biol ; 13(2): R39-40, 2003 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-12546795

RESUMO

The Austrian Academy of Sciences has taken the bold step of closing a successful institute in Salzburg and opening two new ones in Vienna with the aim of creating an internationally attractive critical mass of biological research activity in the capital. Graham Tebb reports.


Assuntos
Academias e Institutos , Áustria , Projetos de Pesquisa
6.
Curr Biol ; 13(2): R41-2, 2003 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-12546796

RESUMO

Josef Penninger, the new director of the planned Institute of Molecular Biotechnology in Vienna, tells Graham Tebb of hurdles but high hopes he has for shaping a new kind of institution in Austria.


Assuntos
Academias e Institutos , Áustria , Projetos de Pesquisa
7.
Curr Biol ; 13(9): R343-5, 2003 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-12725744
SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa