Detalhe da pesquisa
1.
Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
Nature
; 540(7633): 458-461, 2016 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27926736
2.
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFßRI).
Bioorg Med Chem
; 26(5): 1026-1034, 2018 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29422332
3.
Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.
Bioorg Med Chem Lett
; 27(23): 5267-5271, 2017 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29102228
4.
Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers.
Exp Cell Res
; 332(2): 267-77, 2015 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25486070
5.
Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).
Bioorg Med Chem Lett
; 25(19): 4265-9, 2015 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26320619
6.
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg Med Chem Lett
; 24(9): 2206-11, 2014 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24685542
7.
Macrocycle conformational sampling with MacroModel.
J Chem Inf Model
; 54(10): 2680-96, 2014 Oct 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25233464
8.
Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5.
bioRxiv
; 2024 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38014122
9.
The discovery of BMS-457, a potent and selective CCR1 antagonist.
Bioorg Med Chem Lett
; 23(13): 3833-40, 2013 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23707259
10.
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Bioorg Med Chem Lett
; 22(9): 3311-6, 2012 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22475558
11.
Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).
Bioorg Med Chem Lett
; 22(3): 1384-7, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22225639
12.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett
; 22(12): 3946-50, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22608961
13.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett
; 22(12): 3951-6, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22608393
14.
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of ß-secretase (BACE).
Bioorg Med Chem Lett
; 21(22): 6916-24, 2011 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21782431
15.
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorg Med Chem Lett
; 21(22): 6909-15, 2011 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21974952
16.
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Bioorg Med Chem Lett
; 21(1): 537-41, 2011 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21078556
17.
An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads.
Drug Discov Today
; 26(5): 1115-1125, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33497831
18.
BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.
ACS Med Chem Lett
; 12(11): 1753-1758, 2021 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34795864
19.
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.
ACS Med Chem Lett
; 12(6): 969-975, 2021 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34141082
20.
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J Med Chem
; 63(23): 15050-15071, 2020 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33261314